ID A0A2K6C8N6_MACNE Unreviewed; 607 AA.
AC A0A2K6C8N6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=CUB and zona pellucida like domains 1 {ECO:0000313|Ensembl:ENSMNEP00000020025.1};
GN Name=CUZD1 {ECO:0000313|Ensembl:ENSMNEP00000020025.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000020025.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000020025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011719856.1; XM_011721554.1.
DR AlphaFoldDB; A0A2K6C8N6; -.
DR STRING; 9545.ENSMNEP00000020025; -.
DR Ensembl; ENSMNET00000044269.1; ENSMNEP00000020025.1; ENSMNEG00000033847.1.
DR GeneID; 105469936; -.
DR KEGG; mni:105469936; -.
DR CTD; 50624; -.
DR GeneTree; ENSGT00940000154525; -.
DR OMA; CEMEYNS; -.
DR OrthoDB; 3017755at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000033847; Expressed in multicellular organism.
DR GO; GO:0042589; C:zymogen granule membrane; IEA:Ensembl.
DR GO; GO:0032023; P:trypsinogen activation; IEA:Ensembl.
DR CDD; cd00041; CUB; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002:SF27; CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..607
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014452500"
FT TRANSMEM 571..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..146
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 154..265
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 276..519
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 543..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 68142 MW; D6876459DB0FB4C0 CRC64;
MELVKRLMPL ILLILSCLAE LTMAEAEGNS SCSVTLGGAN MAETHKAMIL QLNPSENCTW
TIERPENKSI RLIFSYIQLD PDGSCESENI KVFDGTSSNG PLLGQVCSKN DYVPVFESSA
STLTFQIVTD SARIQRTVFV FYYFFSPNTS IPNCGGYLDT LEGSFTSPNY PNPHPELAYC
VWHIQVEKGY KIKLNFKEIF LEIDKQCKFD FLAIYDGPST NSGLIGQVCG RVTPTFESSS
NSLTVVLSTD YANSYRGFSA SYTSIYAENI NTTSLTCSSD RMRVIISKSY LEAFNSNGNT
LQLKDPTCRP KLSNVVEFSI PLNGCGTIRK VEDQSITYTN IITFSASSPS EVITRQKQLQ
IIVKCEMEHN STVGLIYITE DDVIQNQNAL GKYNTSMALF ESDSFEKTIL ESPYYVDLNQ
TLFVQVSLHT SDPNLVVFLD TCRASPTSDL ASPTYDLIKS GCSRDETCKV YPLFGHYGRF
QFNAFKFLRS LNSVYLQCKV LICDSSDHQS RCSQGCVSRS KRDISSYKWK TDSIIGPIRL
KRDRSASGNS GFQHETHAEE TPNQPFNSLH LFSFMVLVLN VVIVATITVR HFVNQRAYYK
YQKLQNY
//
