ID A0A2K6CAR6_MACNE Unreviewed; 526 AA.
AC A0A2K6CAR6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Suppressor of fused homolog {ECO:0000256|PIRNR:PIRNR011844};
GN Name=SUFU {ECO:0000313|Ensembl:ENSMNEP00000020736.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000020736.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000020736.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator in the hedgehog signaling pathway. Down-
CC regulates GLI1-mediated transactivation of target genes. Part of a
CC corepressor complex that acts on DNA-bound GLI1. May also act by
CC linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the
CC proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this
CC effect is overcome by binding of STK36 to both SUFU and a GLI protein.
CC Negative regulator of beta-catenin signaling. Regulates the formation
CC of either the repressor form (GLI3R) or the activator form (GLI3A) of
CC the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in
CC the cytoplasm and is maintained in a neutral state. Without the Hh
CC signal, the SUFU-GLI3 complex is recruited to cilia, leading to the
CC efficient processing of GLI3FL into GLI3R. When Hh signaling is
CC initiated, SUFU dissociates from GLI3FL and the latter translocates to
CC the nucleus, where it is phosphorylated, destabilized, and converted to
CC a transcriptional activator (GLI3A). {ECO:0000256|PIRNR:PIRNR011844}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}.
CC Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
CC -!- SIMILARITY: Belongs to the SUFU family.
CC {ECO:0000256|PIRNR:PIRNR011844}.
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DR RefSeq; XP_011733812.1; XM_011735510.1.
DR AlphaFoldDB; A0A2K6CAR6; -.
DR SMR; A0A2K6CAR6; -.
DR STRING; 9545.ENSMNEP00000020736; -.
DR Ensembl; ENSMNET00000044985.1; ENSMNEP00000020736.1; ENSMNEG00000034125.1.
DR GeneID; 105478344; -.
DR CTD; 51684; -.
DR GeneTree; ENSGT00390000009747; -.
DR OMA; CQIVGVT; -.
DR OrthoDB; 5385318at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034125; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:1990788; C:GLI-SUFU complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR020941; SUFU-like_domain.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR InterPro; IPR037181; SUFU_N.
DR InterPro; IPR007768; Suppressor_of_fused.
DR InterPro; IPR016591; Suppressor_of_fused_euk.
DR PANTHER; PTHR10928; SUPPRESSOR OF FUSED; 1.
DR PANTHER; PTHR10928:SF2; SUPPRESSOR OF FUSED HOMOLOG; 1.
DR Pfam; PF05076; SUFU; 1.
DR Pfam; PF12470; SUFU_C; 1.
DR PIRSF; PIRSF011844; Suppressor_of_fused_protein; 2.
DR SUPFAM; SSF103359; Suppressor of Fused, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR011844};
KW Developmental protein {ECO:0000256|PIRNR:PIRNR011844};
KW Nucleus {ECO:0000256|PIRNR:PIRNR011844};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 64..240
FT /note="Suppressor of fused-like"
FT /evidence="ECO:0000259|Pfam:PF05076"
FT DOMAIN 253..459
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 58570 MW; A0D66A7DFDD80875 CRC64;
MAELRPSGAP GPTAPPAPGP TAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY
WLGGPDPLDY VSMYRNVGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL
TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT
EDPQMQPVQT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR
GETIFEIDPH LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDDEDSRS ICIGTQPRRL
SGKDTEQIRE TLRRGLEINS KPVLPPINPQ RQNGLAHDRA PSRKDSLESD SSTAIIPHEL
IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI TGDMAITFVS TGVEGAFATE
EHPYAAHGPW LQILLTEEFV EKMLEDLEDL TSPEERLSPH PASLATLVLA ETVPQQRERR
GRQPGRVGLV CLQPQPQFKL PKEYSWPEKK LKVSILPDVV FDSPLH
//
