ID A0A2K6CAV8_MACNE Unreviewed; 1317 AA.
AC A0A2K6CAV8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=ATP binding cassette subfamily B member 11 {ECO:0000313|Ensembl:ENSMNEP00000020794.1};
GN Name=ABCB11 {ECO:0000313|Ensembl:ENSMNEP00000020794.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000020794.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000020794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC {ECO:0000256|ARBA:ARBA00007577}.
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DR Ensembl; ENSMNET00000045043.1; ENSMNEP00000020794.1; ENSMNEG00000034147.1.
DR GeneTree; ENSGT00940000157564; -.
DR OMA; GFGQEEQ; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034147; Expressed in liver.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR43394:SF11; ALPHA-FACTOR-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR43394; ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..379
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 414..650
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 752..1039
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1074..1312
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1317 AA; 145570 MW; DBED8EFD42CCD78A CRC64;
MSDPVILRSV KKFGEENGGF ESDKSCKLQD EKKGDGVRVG FFQLFRFSSS TDIWLMFVGS
LCAFLHGIAQ PGVLLIFGTM TDVFIDYDIE LQELQIPGKA CVNNTIVWTN SSLNQTMTNG
TRCGLLNIES EMIRFASYYA GIAVAVLITG YIQICFWVIA AARQTQKMRK FYFRRIMRME
IGWFDCNSVG ELNTRFSDDI NKINDAIADQ MALFIQRMTS TICGFLLGFF RGWKLTLVII
SVSPLIGIGA ATIGLSVSKF TDYELKAYAK AGVVADEVIS SMRTVAAFGG EKREVERYEK
NLVFAQRWGI RKGIVMGFFT GFVWCLIFLC YALAFWYGST LVLDEGEYTP GTLVQIFLSV
IVGALNLGNA SPCLEAFAAG RAAATSIFET IDRKPIIDCM SEDGYKLDRI KGEIEFHNVT
FHYPSRPEVK ILNNLNMVIK PGEMTALVGP SGAGKSTALQ LIQRLYDPCE GMVTVDGHDI
RSLNIQWLRD QIGIVEQEPV LFSTTIAENI RYGREDATME DIVQAAKEAN AYNFIMDLPQ
QFDTLVGEGG GQMSGGQKQR VAIARALIRN PKILLLDMAT SALDNESEAL VQEALSKIQH
GHTIISVAHR LSTVKAADTI IGFEHGAAVE RGTHEELLER KGVYFTLVTL QSQGNQALNE
EDIKGKDATE DDMLAGTFSR GSYQDSLRAS IRQRSKSQLS YLVHEPPLAV VDHKSTYEED
RKDKDIPVRE EVEPAPVRRI LKFNAPEWPY MLAGSVGAAV NGTVTPLYAF LFSQILGTFA
LPDKDEQRSQ INGVCLLFVA MGCVSLFTQF LQGYAFAKSG ELLTKRLRKF GFRAMLGQDI
GWFDDLRNSP GALTTRLATD ASQVQGAAGS QIGMMVNSFT NVTVAMIIAF YFSWKLSLVI
LCFFPFLALS GATQTRMLTG FASRDKRALE MVGQITNEAL SNIRTVAGIG KERRFIETLE
TELEKPLKTA IQKANVYGFC FAFSQCILFV ANSASYRYGG YLIPNEGLHF SYVFRVISAV
VLSATALGRT FSYTPSYAKA KISAARFFEL LDRQPPISVY SSAGEKWNNF QGKIDFVDCK
FTYPSRPDTQ VLNGLSVSIS PGQTLAFVGS SGCGKSTSIQ LLERFYDPDQ GKVMIDGHDS
KKVNIQFLRS NIGIVSQEPV LFACSIMDNI KYGDNTKEIP VERVIAAAKQ AQLHDFVMSL
PEKYETNVGS QGSQLSRGEK QRIAIARAIV RDPKILLLDE ATSALDTESE KTVQVALDKA
REGRTCIVIA HRLSTIQNAD IIAVMAQGVV IEKGTHEELM AQKGAYYKLV TTGSPIS
//
