ID   A0A2K6CCY2_MACNE        Unreviewed;       481 AA.
AC   A0A2K6CCY2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   Name=CES1 {ECO:0000313|Ensembl:ENSMNEP00000021498.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000021498.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000021498.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC       {ECO:0000256|ARBA:ARBA00004319}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6CCY2; -.
DR   ESTHER; macfa-CES1v1; Carb_B_Chordata.
DR   Ensembl; ENSMNET00000045749.1; ENSMNEP00000021498.1; ENSMNEG00000034468.1.
DR   GeneTree; ENSGT00940000154623; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000034468; Expressed in liver and 8 other cell types or tissues.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00312; Esterase_lipase; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF179; LIVER CARBOXYLESTERASE 1-RELATED; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          21..461
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   481 AA;  53322 MW;  96F8B579AE9909AB CRC64;
     MCSQDAVAGQ VLSELFTNRK ENIPLKLSED CLYLNIYTPA DLTKKNRLPV MVWIHGGGLV
     VGAASTYDGL ALAAHENVVV VTIQYRLGIW GFFSTGDEHS RGNWGHLDQL AALHWVQDNI
     ASFGGNPGSV TIFGESAGGE SVSVLVLSPL AKNLFHRAIS ESGVALTAVL VKKGDVKPLA
     EQIAIAAGCQ TTTSAVMVHC LRQKTEEELL ETTLKMKFFS LDLHGDPRES YPFVGTVVDG
     LLLPKTPEEL QAERKFNTVP YMVGFNKQEF GWIIPMLMGY PLSEGKLDQK TAMSLLWKSY
     PLVYIAKELI PEATEKYLGG TDDPVKKKDL FLDLIADVMF CVPSVIVARH HRDAGAPTYM
     YEFQYRPSFS SDMKPKTVIG DHGDELFSVF GAPFLKEGAS EEEIRLSKMV MKFWANFARN
     GNPNGEGLPH WPEYNQKEGY LQIGANTQAA QKLKDKEVAF WTKLFAKMAV EKPPQTEHIE
     L
//