ID A0A2K6CDH8_MACNE Unreviewed; 3124 AA.
AC A0A2K6CDH8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA polymerase zeta catalytic subunit {ECO:0000256|ARBA:ARBA00021589};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=REV3L {ECO:0000313|Ensembl:ENSMNEP00000021721.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000021721.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000021721.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR RefSeq; XP_011757276.1; XM_011758974.1.
DR STRING; 9545.ENSMNEP00000021721; -.
DR Ensembl; ENSMNET00000045973.1; ENSMNEP00000021721.1; ENSMNEG00000034577.1.
DR GeneID; 105492089; -.
DR KEGG; mni:105492089; -.
DR CTD; 5980; -.
DR GeneTree; ENSGT00940000156226; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034577; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:Ensembl.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR CDD; cd05534; POLBc_zeta; 1.
DR CDD; cd22287; REV3L_RBD; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR032757; DUF4683.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR025687; Znf-C4pol.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 2.
DR Pfam; PF15735; DUF4683; 1.
DR Pfam; PF14260; zf-C4pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 95..191
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 747..1133
FT /note="DUF4683"
FT /evidence="ECO:0000259|Pfam:PF15735"
FT DOMAIN 2266..2478
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 2544..2994
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 3036..3103
FT /note="C4-type zinc-finger of DNA polymerase delta"
FT /evidence="ECO:0000259|Pfam:PF14260"
FT REGION 266..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1958..1980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2014..2149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2211..2230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1060
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1585
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1958..1979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2061..2093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2215..2230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3124 AA; 352106 MW; 04DAFD18AEC7853D CRC64;
MFSVRIVTAD YYMASPLQGL DTCQSPLTQA PVKKVPVVRI FGATPAGQKT CLHLHGIFPY
LYVPYDGYGQ QPESYLSQMA FSIDRALNVA LGNPSSTAQH VFKVSLVSGM PFYGYHEKER
HFMKIYLYNP AVVKRICELL QSGAIMNKFY QPHEAHIPYL LQLFIDYNLY GMNLINLAAV
KFRKARRKSN TLYATGSCKN HLSRNSLAGS LFRWEQDEIP SSLILEGVEP QSTCELEVDA
VAADILNRLD IEAQIGRNPG LQAIWEDEKQ RRRNRNETSQ ISQPESQDHR FVPATESEKK
FQKRLQEILK QNDFSVTLSG SVDYSDGSQE FSAELTLHSE VLSPEMLQCT PANMVEVHKD
KESSKGHTRH KVEEALINEE AILNLMENSQ TFQPLTQRLS ESPVFMDSSP DEALVHLLAG
LESDGYRGER NRMPSPCRSF GNNKYPQNSD DEENEPQIEK EEMELSLVMS QRWDSNIEEH
CAKKRSLCRN THRSSTEDDD SSSEEEMEWS DNSLLLANLS IPQLDGTADE NSDNPLNNEN
SRTHSSVIAT SKLSVKPSIF HKDAATLEPS SSAKITFQCK HTSALSSHVL NKEDLIEDLS
QTNKNIEKGL DNSVTSFTNE STYSVKYPGS LSSTVHSENS HKENSKKEIL PVSSCESSIF
DYEEDIPSVT RQVPSRKYTN IRKIEKDSPF IHMHRHPNEN TLGKNSFNFS DLNHSKNKVS
SEGNEKGNST ALSSLFPSSF TENCELLSCS GENRTMVHSL NSTADESGLN KLKIRYEEFQ
EHKTEKPSLS QQAAHYMFFP SVVLSNCLTR PQKLSPVTYK LQPGNKPSRL KLNKKKLAGH
QETFTKSSET GSTKDNSIQN NPCNSNPEKD SAFASDLTKT SRGAFENKTP TDGFIDCHFG
DGTLETEQSF GLYGNKYTLR AKRKVNYETE DSESSFVTHN SKISLPHPME IGESLDGTLK
SRKRRKMSKK LPPVIIKYII INRFRGRKNM LVKLGKIDAK EKQVILTEEK MELYKKLAPL
KDFWPKVPDS PATKYPIYPL TPKKSHRRKS KHKSAKKKTG KQQRTNNENI KRTLSFRKKR
SHALLSPPSP SYNAETEDCD LNYSDVMSKL GFLSERSTSP INSSPPRCWS PTDPRAEEIM
AAAEKEAMLF KGPNVYNKTV NSRIGKNSRA RAQVKKSKAK LVNPSVVTKK RNKRNQTNKL
VDDGKKKPRA KQKTNAKGTS RKHKTLKDEK IKSQSGAEVK FVLKHQNVSE FASSSGGAQL
LFKQKDMPLM GSAVDHPLSA PLPTGINAQQ KLSGCFSSFL ESKKSVDVQT FPSSRDDLHP
SVVCNSIGPG ISKINVQRPH NQSAIFTLKE STLIQKNVFD LSNHLSQVAQ NTQISSGMSS
KIEDNANNIQ KNYLSSIGKL SEYRNSLESK LDQAYTPNFL HCKDSQQQIV CIAEQSKHSE
TCSPGNTASD ESQMPNNCFV TSLRSPIKQI AWEQKQRGFI LDMSNFKPER VKQRSLSEAI
SQTKALSQCK TPAPSAFGEG QSGLAVLKEL LQKRQQKAQN ANIIQDPLSN KHQPNKNISG
SLEHNKANKR TRSVTSPRKP RTPRSTKPKE KIPKLLKVDS LNLQNSSQLD NSVSDDSPIF
FSDPGFESCY SLEDSLSPEH NYNFDINTIG QTGFCSFYSG SQFVPADQNL PQKFLSDAVQ
DLFPGQAIEK NEFLSHDNQK CEEDKHTTDS ASWIRSGTLS PEIFEKSSID SIENHRHNQW
KNSFHPLTTR SNSIMDSFCV QQAEDCLNEK SRLNRSSVSK EVFLSLPQPN NSDWIQGHTR
KEMGRSLDSA NTSFTAILSS PDGELVDMAC EDLELYVSRN NDMLTPTPDS SPRSTSSPSQ
SKNGSFTPRT AHILKPLMSP PSREEIMATL LDHDLSETIY QEPFCSNPSD VPEKPREIGG
RLLMVETRLA NDLAEFEGDF SLEGLRLWKT AFSAMTQNPR PGSPLRSGQG VVNKGSSNSP
KMVEDKKIVI MPCKCAPSRQ LVQVWLQAKE QYERSKKLPK TKPTGVVKSA ENFSSSVNPD
DKPVVPPKMD VSPRILPTTA HTKEDVNSRI ALQAPTTGCS QTASESQMLP PVASSSDPEK
DEDDDNYYIN YSSPDSPVIP PWQQPVSPDS KALNGDDRPS SPVEELPSLG VENFLKPIKD
GIQKSPCSEP QEPLVISPIN ARARTEKCES LCLHSTPIIQ RKLLERLPEA TGLSPLSTEP
KTQKLSNKKG SNTDTLRRVL LTQAKNQFAA VNTPQKETSQ IDGPSLNNTY GFKVSIQNLQ
EAKALHEIQN LTLISVELHA RTRRDLEPDP EFDPICALFY CISSDAPLPD TEKTELTGVI
VIDKDKTVFS QDIRYQTPLL IRSGITGLEV TYAADEKALF HEIANIIKRY DPDILLGYEI
QMHSWGYLLQ RAAALSVDLC QMISRVPDDK IENRFAAERD EYGSYTMSEI NIVGRITLNL
WRIMRNEVAL TNYTFENVSF HVLHQRFPLF TFRVLSDWFD NKTDLYRWKM VDHYVSRVRG
NLQMLEQLDL IGKTSEMARL FGIQFLHVLT RGSQYRVESM MLRIAKPMNY IPVTPSVQQR
SQMRAPQCVP LIMEPESRFY SNSVLVLDFQ SLYPSIVIAY NYCFSTCLGH VENLGKYDEF
KFGCTSLRVP PDLLYQVRHD ITVSPNGVAF VKPSVRKGVL PRMLEEILKT RFMVKQSMKA
YKQDRALSRM LDARQLGLKL IANVTFGYTA ANFSGRMPCI EVGDSIVHKA RETLERAIKL
VNDTKKWGAR VVYGDTDSMF VLLKGATKEQ SFKIGQEIAE AVTATNPKPV KLKFEKVYLP
CVLQTKKRYV GYMYETLDQK DPVFDAKGIE TVRRDSCPAV SKILERSLKL LFETRDISLI
KQYVQRQCMK LLEGKASIQD FIFAKEYRGS FSYKPGACVP ALELTRKMLT YDRRSEPQVG
ERVPYVIIYG TPGVPLIQLV RRPVEVLQDP TLRLNATYYI TKQILPPLAR IFSLIGIDVF
SWYHELPRIH KATNSSRSEP EGRKGTISQY FTTLHCPVCD DLTQHGICSK CRSQPQHVAV
ILNQEIRELE RKQEQLVKIC KNCTGCFDRH IPCVSLNCPV LFKVSRVNRE LSKAPYLRQL
LDQF
//
