ID A0A2K6CEC2_MACNE Unreviewed; 328 AA.
AC A0A2K6CEC2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Small RNA binding exonuclease protection factor La {ECO:0008006|Google:ProtNLM};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000022013.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000022013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K6CEC2; -.
DR STRING; 9545.ENSMNEP00000022013; -.
DR Ensembl; ENSMNET00000046265.1; ENSMNEP00000022013.1; ENSMNEG00000034698.1.
DR GeneTree; ENSGT00830000128380; -.
DR OMA; WNKEVTW; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034698; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd08028; LARP_3; 1.
DR CDD; cd12291; RRM1_La; 1.
DR CDD; cd12541; RRM2_La; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR014886; La_xRRM.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792:SF172; LUPUS LA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR22792; LUPUS LA PROTEIN-RELATED; 1.
DR Pfam; PF05383; La; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF08777; RRM_3; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS51939; XRRM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00332}.
FT DOMAIN 7..99
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50961"
FT DOMAIN 103..179
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 198..323
FT /note="XRRM"
FT /evidence="ECO:0000259|PROSITE:PS51939"
FT REGION 308..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 37618 MW; 1C174683F0D99BD6 CRC64;
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKLLREQM KLDEGWVSLE IMIKFNRLNC
LTTDFNVIVE TLSKSVAELM EISEDKTKIR RSPSKPLPEV TDESVYIKGF QTDATLDDIK
EWLEDKGQVL NTQMRRTLHK TFKGSIFVVF DSIESTKKFV EAPGQKYKDT GLLILFKDNY
FQEANQKLEE DAEKKSLEKK IGCLLKFSGD LDDQTCREDL HILISNHGEI KWIDFIRGAK
EGIILFKVKA KEALGKAKDA NNGNLQLWNK EVTWEVLEGE VEKEALKKIT EDQQESLNIW
KSKGCRFKGK GKGNKAAYPG SGKEKVQF
//
