ID A0A2K6CEW9_MACNE Unreviewed; 942 AA.
AC A0A2K6CEW9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zinc finger protein 268 {ECO:0000313|Ensembl:ENSMNEP00000022199.1};
GN Name=ZNF268 {ECO:0000313|Ensembl:ENSMNEP00000022199.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000022199.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000022199.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_011754674.1; XM_011756372.1.
DR RefSeq; XP_011754675.1; XM_011756373.1.
DR RefSeq; XP_011754677.1; XM_011756375.1.
DR RefSeq; XP_011754678.1; XM_011756376.1.
DR AlphaFoldDB; A0A2K6CEW9; -.
DR Ensembl; ENSMNET00000046453.1; ENSMNEP00000022199.1; ENSMNEG00000034776.1.
DR GeneID; 105490583; -.
DR KEGG; mni:105490583; -.
DR GeneTree; ENSGT00940000163459; -.
DR OMA; AKGYECT; -.
DR OrthoDB; 4637982at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034776; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 24.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF398; ZINC FINGER PROTEIN 715; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 23.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 24.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 13.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 24.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 24.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 76..147
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 271..298
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 299..326
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 327..354
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 355..382
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 383..410
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 411..438
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 439..466
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 467..494
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 495..522
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 523..550
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 551..578
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 579..606
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 607..634
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 635..662
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 663..690
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 691..718
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 719..746
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 747..774
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 775..802
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 803..830
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 831..858
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 859..886
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 887..914
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 915..942
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 942 AA; 107800 MW; 2C7FFB340011D1A0 CRC64;
MATRVRTASI WVPPLQERNS SWDRIRKLQG QESVLGLQHL PGAPRQKRKS RRTEKVLEWL
FISQEQPKIT TSWGPLSFMD VFVDFTWEEW QLLDPAQKCL YRNVMLENYS NLVSLGYQHT
KPDIIFKLEQ GEELCVVQAQ IPNQSCPNTV WKIDDLMEWH QENKDKLGST AKSFECTTFG
KLCLLSTNYL SRQKPHKCGT HGKGLKYIDF TSNYAGKNPN GFQVHGKSFF HSKQEQSVIG
IKYCESNESG KAVNKKSQLM CQQVYMGEKP FGCSYCKKAF SSKSYLVVHQ RTHAEEKPYG
CNECGKDFSS KSYLIVHQRI HTGEKLHECG ECGKTFSFNS QLVMHQRIHT GENPYECCEC
GKVFSRKDQL VSHQKTHSGW KPYVCNECGK AFGLKSQLII HERIHTGEKP YECNECQKAF
NTKSNLMVHQ RTHTGEKPYV CSDCGKAFTF KSQLIVHQGI HTGVKPYGCI QCGKAFSLKS
QLIVHQRSHT GMKPYVCNEC GKAFRSKSYL IIHTRTHTGE KLHECNNCGK AFSFKSQLII
HQRIHTGENP YECHECGKAF SRKYQLISHQ RIHAGEKPYE CTDCGKAFGL KSQLIIHQRT
HTGEKPFECS ECPKAFNTKS NLIVHQRTHT GEKPYGCNEC GKAFTFKSQL IVHQGVHTGV
KPYGCSQCEK TFSLKSQLIV HQRSHTGVKP YGCSECGKAF RSKSYLIIHT RTHTGEKPHE
CRECGKSFSF NSQLIVHQRI HTGENPYECS ECGKAFNRKD QLISHQRTHV GEKPYGCSEC
GKAFSSKSYL IIHMRTHSGE KPYECNECGK AFIWKSLLIV HERTHARVNP YKCSQCEKSF
GGKLRLLVHQ RMHTREKPYE CSECGKAFIR NSQLIVHQRT HSGEKPYGCN ECGKTFSQKS
ILSAHQRTHT GEKPCKCTEC GKAFCWKSQL IMHQRTHVDD KH
//
