ID A0A2K6CFQ4_MACNE Unreviewed; 580 AA.
AC A0A2K6CFQ4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Interleukin 10 receptor subunit alpha {ECO:0000313|Ensembl:ENSMNEP00000022496.1};
GN Name=IL10RA {ECO:0000313|Ensembl:ENSMNEP00000022496.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000022496.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000022496.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011730679.1; XM_011732377.1.
DR AlphaFoldDB; A0A2K6CFQ4; -.
DR STRING; 9545.ENSMNEP00000022496; -.
DR Ensembl; ENSMNET00000046752.1; ENSMNEP00000022496.1; ENSMNEG00000034917.1.
DR GeneID; 105476423; -.
DR KEGG; mni:105476423; -.
DR CTD; 3587; -.
DR GeneTree; ENSGT00510000048847; -.
DR OMA; TGQWNQP; -.
DR OrthoDB; 5347858at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034917; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0004920; F:interleukin-10 receptor activity; IEA:Ensembl.
DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF88; INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..580
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014444957"
FT TRANSMEM 236..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..111
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF01108"
FT REGION 312..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 63359 MW; A9D10EC253D94EC4 CRC64;
MLPRLVVLLA AFLSRRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA
LLRYGTGRWN SISNCSQALS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSL
DEVTLTVGSV KLEIHNGFIL GKIQPPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF
THKKVKHENF SLLTSGEVGE FCVQVKPSVT SRTNKGMWSK EECVSLTRQY FTVTNVIIFF
AFVLLLSGAL AYCLALQLYV RRRKKLPRVL LFKKPNAFIF ISQRPSPETQ DTIHPLDEEA
FLKVSPELRN SDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN GEPPELGNSC
SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSDSRGQDD SGIGLVQNSE GQAGDTQGGS
ALGHDSAPEP EVPAEQDPTA VVFRGYLRQT RCAEEKATKT GCLEEELPLT GGLGPKFRGC
LDDEAGLHPS ALAKGYLKQD PLEMTLASSG APTEQWNQPT EEWSLLALSS CSDLGTSDWS
FAHDLAPLGC VAAPDGLLGS FNSDLVTLPL ISSLHSSDSS
//
