ID A0A2K6CG12_MACNE Unreviewed; 469 AA.
AC A0A2K6CG12;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Keratin, type II cytoskeletal 7 {ECO:0000256|ARBA:ARBA00039431};
DE AltName: Full=Cytokeratin-7 {ECO:0000256|ARBA:ARBA00042963};
DE AltName: Full=Keratin-7 {ECO:0000256|ARBA:ARBA00042887};
DE AltName: Full=Type-II keratin Kb7 {ECO:0000256|ARBA:ARBA00043134};
GN Name=KRT7 {ECO:0000313|Ensembl:ENSMNEP00000022582.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000022582.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000022582.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit
CC EIF3S10. Interacts with GPER1. {ECO:0000256|ARBA:ARBA00038822}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_011727202.1; XM_011728900.1.
DR AlphaFoldDB; A0A2K6CG12; -.
DR STRING; 9545.ENSMNEP00000022582; -.
DR Ensembl; ENSMNET00000046838.1; ENSMNEP00000022582.1; ENSMNEG00000034954.1.
DR GeneID; 105474326; -.
DR KEGG; mni:105474326; -.
DR CTD; 3855; -.
DR GeneTree; ENSGT00940000161303; -.
DR OMA; QRSKQEM; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000034954; Expressed in lung and 2 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 91..403
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 446..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 88..115
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 166..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 301..378
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 455..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 51572 MW; 19F3D986FD433DFC CRC64;
MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA VRSAYGGPVG
AGIREVTINQ SLLAPLRLDA DPSLQRVRQE EREQIKTLNN KFASFIDKVR FLEQQNKLLE
TKWTLLQEQK SAKSSRLPDV FEAQIAGLRG QLEALQVDGG RLEAELQSMQ DVVEDFKNKY
EDEINRRAAA ENEFVVLKKD VDAAYMSKVE LEAKVDALND EINFLRTLNE MELTELQSQI
SDTSVVLSMD NSRSLDLDSI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD
LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA RAKQEELEAA
LQRTKQDMVR QLREYQELMS VKLALDIEIA TYRKLLEGEE SRLAGDGVGA VNISVVNSTG
GSSNGGGIGL TLGGTMGSNA LSFSSSAGPG PLKAYSIRTT STSRRSARN
//
