ID A0A2K6CL22_MACNE Unreviewed; 407 AA.
AC A0A2K6CL22;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Myeloid cell nuclear differentiation antigen {ECO:0000313|Ensembl:ENSMNEP00000024342.1};
GN Name=MNDA {ECO:0000313|Ensembl:ENSMNEP00000024342.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000024342.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000024342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011768295.1; XM_011769993.1.
DR RefSeq; XP_011768297.1; XM_011769995.1.
DR AlphaFoldDB; A0A2K6CL22; -.
DR SMR; A0A2K6CL22; -.
DR STRING; 9545.ENSMNEP00000024342; -.
DR Ensembl; ENSMNET00000048609.1; ENSMNEP00000024342.1; ENSMNEG00000035719.1.
DR GeneID; 105498125; -.
DR KEGG; mni:105498125; -.
DR CTD; 4332; -.
DR GeneTree; ENSGT00390000013296; -.
DR OMA; CQVDARR; -.
DR OrthoDB; 4893941at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000035719; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR PANTHER; PTHR12200:SF27; MYELOID CELL NUCLEAR DIFFERENTIATION ANTIGEN; 1.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..88
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 196..394
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 122..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 45978 MW; A481F2248EC80CE3 CRC64;
MANEYKKILL LKGLELMDEY HFIIIKSLLA YDLGLTTKMQ EEYNRIKISD LMEKKFQGVA
CVDKLIELAK DMPPLKNLVN NLRKERSKVA RKMKAQGVVL MKKINQEEVG LVAPAPTARN
TLTSEVGERI PVAQKRKTLN KGKTEAKRIK VPQEQSEPPR PSGASTSAAT DHPPLPHTSS
STPSNTSFAQ NQQTQAQCQV DTRRNVPQKD PVTVMVLKAT APFKYESPEH GKSTMFHATV
ASKTQYFHVK VFDISLKEKF IRKKVITISD YSECKGVMEI KEASSVSDFD QNFEVPNRII
EIANKTPKIS QLYKQASGTM VYGLFMVQKK SIHKKNTIYE IKDNTGSMDV VGNGKWHNIK
CEKGDKLRLF CFQLRTVNRK LKLVCGSHSF IKVIKAKKNK EGSMNVN
//
