ID A0A2K6CL91_MACNE Unreviewed; 713 AA.
AC A0A2K6CL91;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Neuronal guanine nucleotide exchange factor {ECO:0000313|Ensembl:ENSMNEP00000024423.1};
GN Name=NGEF {ECO:0000313|Ensembl:ENSMNEP00000024423.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000024423.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000024423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011726391.1; XM_011728089.1.
DR AlphaFoldDB; A0A2K6CL91; -.
DR STRING; 9545.ENSMNEP00000024423; -.
DR Ensembl; ENSMNET00000048690.1; ENSMNEP00000024423.1; ENSMNEG00000035677.1.
DR GeneID; 105473903; -.
DR CTD; 25791; -.
DR GeneTree; ENSGT01030000234571; -.
DR OrthoDB; 12272at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000035677; Expressed in temporal lobe and 3 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11939; SH3_ephexin1; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035635; Ephexin-1_SH3.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF8; EPHEXIN-1; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 276..460
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 492..604
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 615..676
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 82569 MW; 59857E25C815EDF0 CRC64;
METKESEDLE KTQRKSRVIS ASDQQKNIDN EPVEVKPELL PEKETSQADQ DVQDKEPHSH
SPIKRNSIFN RSIRRRSKAK ARDTPERNAS CLADSQDNGK SVNESLTLNI PCSRMPPWRT
AVQTGPGAQK MSESSSTPGN GATPEEWPAL ADSPTTLTEA LRMIHPIPAD SWRNLIEQIG
LLYQEYRDKS TLQEIETRRQ QDAEIEDNTN GSPASEDTPE EEEEEEEEEP ASPPERKALP
QICLLSNPHS RFNLWQDLPE IRSSGVLEIL QPEEIKLQEA MFELVTSEAS YYKSLNLLVS
HFMENERMRK ILHPSEAHIL FSNVLDVLAV SERFLLELEH RMEENIVISD VCDIVYRYAA
DHFSVYITYV SNQTYQERAY KQLLQEKAAF RELISQLELD PKCKGLPFSS FLILPFQRIT
RLKLLVQNIL KRVEERSERE CTALDAHKEL EMVVKACNEG VRKMSRTEQM ICIQKKMEFK
IKSVPIISHS RWLLKQGELQ QMSGPKTSRT LRTKKLFHEI YLFLFNDLLV ICRQIPGDKY
QVFDSAPRGL LRVEELEDQG QTLANVFILR LLENADDREA TYMLKASSQS EMKRWMTSLA
PNRRTKFVSF TSRLLDCPQV QCVHPYVAQQ PDELTLELAD ILNILDKTDD GWIFGERLHD
QERGWFPSSM TEEILNPKIR SQNLKECFRV HKMDDPQRSQ NKDRRKLGSR NRQ
//
