ID   A0A2K6CLB1_MACNE        Unreviewed;       731 AA.
AC   A0A2K6CLB1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=RAS p21 protein activator 4 {ECO:0008006|Google:ProtNLM};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000024443.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000024443.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_011758316.1; XM_011760014.1.
DR   AlphaFoldDB; A0A2K6CLB1; -.
DR   Ensembl; ENSMNET00000048710.1; ENSMNEP00000024443.1; ENSMNEG00000035704.1.
DR   GeneID; 105492755; -.
DR   GeneTree; ENSGT00940000160149; -.
DR   OMA; VGCDKTR; -.
DR   OrthoDB; 24454at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000035704; Expressed in skeletal muscle tissue and 9 other cell types or tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   CDD; cd04025; C2B_RasA1_RasA4; 1.
DR   CDD; cd13372; PH_CAPRI; 1.
DR   CDD; cd05395; RasGAP_RASA4; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR037777; RASA4_PH.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   DOMAIN          44..160
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          230..440
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          494..601
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          708..731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        711..731
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   731 AA;  82303 MW;  F4B14635AA853F02 CRC64;
     MDEDALSRDD VIGKVCLPRD TLASHPKGFS GWTHLTEVDP DEEVQGEIHL RLEVQPGTRA
     CRLRCSVLEA RDLAPKDRNG ASDPFVRVRY KGRTQETSIV KKSCYPRWNE TFEFELEEGA
     TEVLCVETWD WDLVSRNDFL GKVVIDIQRL QVAQPEEGWF RLQPYQTKSR RHDEGNLGSL
     QLEVRLRDEM VLPSSCYQPL VQLLCHEVKL GMQGPGQLIS LIEETTSTEC RQDVATNLLK
     LFLGQGLAKD FLDLLFQLEL SRTSETNTLF RSNSLASKSM ESFLKVAGMQ YLHGVLGPII
     NKVFEEKKYV ELDPSKVEVK DVGCSGLHRP QTEAEVLEQS AQTLRAHLGA LLSALSRSVR
     ACPAVVRATF RQLFRRVRER FPGAQHENVP FIAVTSFLCL RFFSPAIMSP KLFHLRERHA
     DARTSRTLLL LAKAVQNVGN MDTPASRAKE AWMEPLQPTV RQGVAQLKDF ITKLVDIEEK
     DELDLQRTLS LQAPPVKEGP LFIHRTKGKG PLMSSSFKKL YFFLTTEALS FAKTPSSKKS
     ALIKLANIRA AEKVEEKSFG SSHVMQVIYT DDVGRPQTAY LQCKCVNELN QWLSALRKVS
     INNTGLLGSY HPGVFRGDKW SCCHQKEKTG QGCDKTRSRV TLQEWNDPLD HDLEAQLIYR
     HLLGVEAMLW ERHRELSRGA EAGTVPASPG EAPKDSLAQL LRVLQDLREA HSSSPAGSPP
     SEPNCLLELQ T
//