ID A0A2K6CM73_MACNE Unreviewed; 990 AA.
AC A0A2K6CM73;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Semaphorin 6D {ECO:0000313|Ensembl:ENSMNEP00000024754.1};
GN Name=SEMA6D {ECO:0000313|Ensembl:ENSMNEP00000024754.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000024754.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000024754.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A2K6CM73; -.
DR Ensembl; ENSMNET00000049024.1; ENSMNEP00000024754.1; ENSMNEG00000035871.1.
DR GeneTree; ENSGT00940000159303; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000035871; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..990
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014389341"
FT TRANSMEM 580..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..491
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 661..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 110538 MW; AFC4AEAC68589F31 CRC64;
MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ
LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPSKDECHNF IKVFVPRNDE MVFVCGTNAF
NPMCRYYRLS TLEYDGEEIS GLARCPFDAR QTNVALFADG KLYSATVADF LASDAVIYRS
MGDGSALRTI KYDSKWIKEP HFLHAIEYGN YVYFFFREIA VEHNNLGKAV YSRVARICKN
DMGGSQRVLE KHWTSFLKAR LNCSVPGDSF FYFDVLQSIT DIIQINGIPT VVGVFTTQLN
SIPGSAVCAF SMDDIEKVFK GRFKEQKTPD SVWTAVPEDK VPKPRPGCCA KHGLAEAYKT
SIDFPDETLS FIKSHPLMDS AVPPIADEPW FTKTRVRYRL TAIAVDHSAG PYQNYTVIFV
GSEAGVVLKV LAKTSPFSLN DSVLLEEIEA YNHAKCSAEN EEDKKVISLQ LDKDHHALYV
AFSSCVVRIP LSRCERYGSC KKSCIASRDP YCGWLSQGSC GRVTPGMLLL TEDLFAFHNH
SAEGYEQDTE FGNTAHLGDC HGVRWEVQSG ESNQMVHMNV LITCVFAAFV LGAFIAGVAV
YCYRDMFVRK NRKIHKDAES AQSCTDSSGS FAKLNGLFDS PVKEYQQNID SPKLYSNLLT
SRKELPPNGD TKSMVMDHRG QPPELAALPT PESTPVLHQK TLQAMKSHSE KAHGHGASRK
ETPQFFPSSP PPHSPLSHGH IPSAIVLPNA THDYNTSFSN SNAHKAEKKL QNIDHPLTKS
SSKRDHRRSV DSRNTLNDLL KHLNDPNSNP KAIMGDIQMA HQNLMLDPVG SMSEVPPKVP
NREASLYSPP STLPRNSPTK RVDVPTTPGV PMTSLERQRG YHKNSSQRHS ISAMPKNLNS
PNGVLLSRQP SMNRGGYMPT PTGAKVDYIQ GTPVSVHLQP SLSRQSSYTS NGTLPRTGLK
RTPSLKPDVP PKPSFVPQTP SVRPLNKYTY
//
