ID A0A2K6CN13_MACNE Unreviewed; 548 AA.
AC A0A2K6CN13;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Polypyrimidine tract binding protein 3 {ECO:0000313|Ensembl:ENSMNEP00000025048.1};
GN Name=PTBP3 {ECO:0000313|Ensembl:ENSMNEP00000025048.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000025048.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000025048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6CN13; -.
DR Ensembl; ENSMNET00000049322.1; ENSMNEP00000025048.1; ENSMNEG00000035996.1.
DR GeneTree; ENSGT01050000244924; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000035996; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0045595; P:regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:UniProt.
DR CDD; cd12779; RRM1_ROD1; 1.
DR CDD; cd12784; RRM2_ROD1; 1.
DR CDD; cd12703; RRM4_ROD1; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR033110; PTBP3_RRM4.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034326; ROD1_RRM1.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF17; POLYPYRIMIDINE TRACT-BINDING PROTEIN 3; 1.
DR Pfam; PF13893; RRM_5; 2.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 55..139
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 178..254
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 354..428
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 471..546
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 431..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 59320 MW; 9E95285057FB86F4 CRC64;
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMGVYANGND SKKFKRDRPP CSPSRVLHLR
KIPCDVTEAE IISLGLPFGK VTNLLMLKGK SQAFLEMASE EAAVTMVNYY TPVTPHLRSQ
PVYIQYSNHR ELKTDNLPNQ ARAQAALQAV SAVQSGSLAL SGGPSNEGTV LPGQSPVLRI
IIENLFYPVT LEVLHQIFSK FGTVLKIITF TKNNQFQALL QYADPVNAHY AKMALDGQNI
YNACCTLRID FSKLTSLNVK YNNDKSRDFT RLDLPTGDGQ PSLEPPMAAA FGAPGIISSP
YAGAAGFAPA IGFPQATGLS VPAVPGALGP LTITSSAVTG RMAIPGASGI PGNSVLLVTN
LNPDLITPHG LFILFGVYGD VHRVKIMFNK KENALVQMAD ANQAQLAMNH LSGQRLYGKV
LRATLSKHQA VQLPREGQED QGLTKDFSNS PLHRFKKPGS KNFQNIFPPS ATLHLSNIPP
SVTVDDLKNL FIEAGCSVKA FKFFQKDRKM ALIQLGSVEE AIQALIELHN HDLGENHHLR
VSFSKSTI
//
