ID A0A2K6CNL1_MACNE Unreviewed; 525 AA.
AC A0A2K6CNL1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Zinc finger protein 181 {ECO:0000313|Ensembl:ENSMNEP00000025248.1};
GN Name=ZNF181 {ECO:0000313|Ensembl:ENSMNEP00000025248.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000025248.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000025248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K6CNL1; -.
DR Ensembl; ENSMNET00000049523.1; ENSMNEP00000025248.1; ENSMNEG00000036115.1.
DR GeneTree; ENSGT00940000161431; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036115; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24377; IP01015P-RELATED; 1.
DR PANTHER; PTHR24377:SF1000; ZINC FINGER PROTEIN 302; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00614; ZnF_BED; 3.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 4..77
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 191..218
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 219..246
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 247..274
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 275..302
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 303..330
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 331..358
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 359..386
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 387..414
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 415..442
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 443..470
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 471..498
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 525 AA; 60585 MW; DCF8D5BDA44073B5 CRC64;
LFQVTFSDVA IDFSHEEWAW LDSAQRDLYK DVMVQNYENL SYVFSGGFIS YPFLLITLGK
KKSSALWENK ELSTKKDIYD EDSPQTVTIE KVVKRRFEFP NSNKNLKYIE CNKFRSTFHS
KSTLSEPQNN SAEGNSHKYD ILKKNVSKKS VIKNERINGG KKLLNSNKSG AAFNQSKSLI
LPHTCNRAKI YTCSECGKAF GKQSILNRHW RIHTGEKPYE CRECGKTFSH GSSLTRHQIS
HSGEKPYKCV ECGKAFSHGS SLTNHQSTHT GEKPYECMNC GKSFSRVSLL IQHLRIHTQE
KRYECRICGK AFIHRSSLIH HQKIHTGEKP YECRECGKAF CCSSHLTRHQ RIHTMEKQYE
CNKCLKVFSS LSFLVQHQSI HTEEKPFECQ KCRKSFNQLE SLNMHLRNHI RLKPYECSIC
GKAFSHRSSL LQHHRIHTGE KPYECIKCGK TFSCSSNLTV HQRIHTGEKP YKCNECGKAF
SKGSNLTAHQ RVHNGGKPNN VVSVEKPLDH MNHYTCEKPY RRETI
//
