ID A0A2K6CNN8_MACNE Unreviewed; 594 AA.
AC A0A2K6CNN8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zinc finger protein 181 {ECO:0000313|Ensembl:ENSMNEP00000025252.1};
GN Name=ZNF181 {ECO:0000313|Ensembl:ENSMNEP00000025252.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000025252.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000025252.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K6CNN8; -.
DR STRING; 9545.ENSMNEP00000025252; -.
DR Ensembl; ENSMNET00000049527.1; ENSMNEP00000025252.1; ENSMNEG00000036115.1.
DR GeneTree; ENSGT00940000161431; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036115; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24377; IP01015P-RELATED; 1.
DR PANTHER; PTHR24377:SF1000; ZINC FINGER PROTEIN 302; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00614; ZnF_BED; 3.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 34..106
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 260..287
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 288..315
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 316..343
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 344..371
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 372..399
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 400..427
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 428..455
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 456..483
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 484..511
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 512..539
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 540..567
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 594 AA; 68639 MW; F2F01E83518899F0 CRC64;
QYPEWYLAPN RCLVMNKMSN EELMGQNHGM EREVTFSDVA IDFSHEEWGW LDSAQRDLYK
DVMVQNYENL VSVAGLSVTK PYVIMLLEDG KEPWMVEKKL SKGMIPDWES RWESKELSTK
KDIYDEDSPQ TVIIEKVVKQ SYEFSNSKKN LEYIEKLEGK HGSQVEHFRP ATLTFRESPT
PDSIYTFHSK STLFETQKIS AEGNSHKYAI LKKNLPKKSV VKNEKISGGK KLLNSSISGA
AFHQSKSLTL HQTCNREKIY ICSECGKAFG KQSILNRHWR IHTGEKPYEC RECGKTFSHG
SSLTRHLISH SGEKPYKCVE CGKAFSHVSS LTNHQSTHTG EKPYECMNCG KSFSRVSHLI
EHLRIHTQEK LYECRICGKA FIHRSSLIHH QKIHTGEKPY ECRECGKAFC CSSHLTRHQR
IHTMEKQYEC NKCLKVFSSL SFLVQHQSIH TEEKPFECQK CRKSFNQLES LNMHLRNHIR
LKPYECSICG KAFSHRSSLL QHHRIHTGEK PYECIKCGKT FSCSSNLTVH QRIHTGEKPY
KCNECGKAFS KGSNLTAHQR VHNGGKPNNV VSVEKPLDHM NHYTCEKPYR RETI
//
