ID   A0A2K6CNY6_MACNE        Unreviewed;       238 AA.
AC   A0A2K6CNY6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain-containing protein {ECO:0000259|Pfam:PF02882};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000025359.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000025359.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6CNY6; -.
DR   Ensembl; ENSMNET00000049634.1; ENSMNEP00000025359.1; ENSMNEG00000036158.1.
DR   GeneTree; ENSGT00940000154863; -.
DR   Proteomes; UP000233120; Unplaced.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099:SF15; BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          110..208
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   238 AA;  25718 MW;  2B96249E2F4A2023 CRC64;
     AATSLTSALA SGLPQPVHSC FLRPHPFHLA AVRDEVVVIS GRKLAQQFKQ EWVASGNKWP
     HLSVILVGEN SASHSYVLNK TRAALPLPEH IDERRICNAV SPDKDVDGFH VINVGRMCLD
     QYSTLPATPW GVWEIIKRTG IPTLGKNVVV AGRSKNVGMP FVMLLHTDGA HERPGGDATV
     TVSHRYTPKE QSKKHTIFAD IVISAAGVGE KAGYITPVPG LAVLMKNTII AGCGWSRL
//