ID A0A2K6CNY9_MACNE Unreviewed; 882 AA.
AC A0A2K6CNY9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC1 {ECO:0000313|Ensembl:ENSMNEP00000025385.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000025385.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000025385.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR RefSeq; XP_011743793.1; XM_011745491.1.
DR AlphaFoldDB; A0A2K6CNY9; -.
DR SMR; A0A2K6CNY9; -.
DR Ensembl; ENSMNET00000049660.1; ENSMNEP00000025385.1; ENSMNEG00000036129.1.
DR GeneID; 105484141; -.
DR CTD; 83857; -.
DR GeneTree; ENSGT00940000158027; -.
DR OMA; TRWHTWR; -.
DR OrthoDB; 155869at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036129; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SMART; SM00386; HAT; 3.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 310..364
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 483..516
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 548..581
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 582..615
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 616..649
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 683..716
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 751..784
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 789..822
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 823..856
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 98835 MW; 151F7402F7C376C0 CRC64;
MVLTTSARGG GGDRAPSRRQ GCGLAPAGAA ALLAGASCLC YGRSLQGEFV HDDVWAIVNN
PDVRPGAPLR WSIFTNDFWG KGMAENTSHK SYRPLCVLTF KLNIFLTGMN PFYFHAVNVI
LHCLVTLVLM YTCDKTVFKN RGLAFVTALL FAVHPIHTEA VAGIVGRADV LACLLFLLAF
LSYNRSLDQG CVGESFPSTV SPFFLLFSLF LGTCAMLVKE TGITVFGVCL VYDLFSLSNK
EDKSSNGALC PCSPQQPGSP QPSSLPGHPH RENGKQQRFP HKGAWGGCHS PLPPEPKSSG
FPVSPRAVWS MMRFLTYSYL LAFNVWLLLA PVTLCYDWQV GSIPLVETIW DMRNLATILL
AVVMALLSLH CLAAFKRLEH KEVLVGLLFL VFPFIPASNL FFRVGFVVAE RVLYMPSMGY
CILFVHGLSK LCTWLNRCGA TTLIVSTVLL LLLFSWKTVK QNEIWLSRES LFRSGVQTLP
HNAKVHYNYA NFLKDQGRNK EAIYHYRTAL KLYPRHASAL NNLGTLIRDT AEAKMYYQKA
LQLHPQHNRA LFNLGNLLKS QEKKEEAITL LKDSIKYGPE FADAYSSLAS LLAEQERFKE
AEEIYQAGIK NCPDSSDLHN NYGVFLVDTG LPEKAVAHYQ QAIKLSPSHH VAMVNLGRLY
RSLGENSMAE EWYKRALQVA HKAEILSPLG ALYYNTGRYE EALQIYQEAA ALQPSQRELR
LALAQVLAVM GQTKEAEKMT NHIVSEETGC LECYRLLSAI YSKQENHDKA LDVIEKALQL
KPKDPKVISE LFFTKGNQLR EQNLLDKAFE SYRVAVQLNP DQAQAWMNMG GIQHIKGKYV
SARAYYERAL QLVPDSKLLK ENLAKLDRLE KRLQEVREKD QT
//
