ID A0A2K6CP29_MACNE Unreviewed; 490 AA.
AC A0A2K6CP29;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Transcription factor EB {ECO:0000313|Ensembl:ENSMNEP00000025451.1};
GN Name=TFEB {ECO:0000313|Ensembl:ENSMNEP00000025451.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000025451.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000025451.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR RefSeq; XP_011752881.1; XM_011754579.1.
DR AlphaFoldDB; A0A2K6CP29; -.
DR SMR; A0A2K6CP29; -.
DR STRING; 9545.ENSMNEP00000025451; -.
DR Ensembl; ENSMNET00000049726.1; ENSMNEP00000025451.1; ENSMNEG00000036203.1.
DR GeneID; 105489619; -.
DR CTD; 7942; -.
DR GeneTree; ENSGT00940000159691; -.
DR OrthoDB; 3061893at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036203; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0140367; P:antibacterial innate immune response; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:InterPro.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18927; bHLHzip_TFEB; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024098; bHLHzip_TFEB.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF5; TRANSCRIPTION FACTOR EB; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 249..302
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 26..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..403
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 54329 MW; 4F2E9C557B82E4F6 CRC64;
MTASSGWEPA PAATMASRIG LRMQLMREQA QQEEQRERMQ QQAVMHYMQQ QQQQQQQQLG
GPPTPAINTP VHFQSPPPVP GEVLKVQSYL ENPTSYHLQQ SQHQKVREYL SETYGNKFAA
HISPAQGSPK PPPAASPGVR AGHVLSSSAG NSAPNSPMAM LHIGSNPERE FDDVIDNIMR
LDDVLGYINP EMQMPNTLPL SSSHLNVYSS DPQVTASLVG VTSSSCPADL TQKRELTDAE
SRALAKERQK KDNHNLIERR RRFNINDRIK ELGMLIPKAN DLDVRWNKGT ILKASVDYIR
RMQKDLQKSR ELENHSRRLE MTNKQLWLRI QELEMQARVH GLPTTSPSGM NMAELAQQVV
KQELPSEEGP GEALMLGAEV PDPEPLPALP PQAPLPLPTQ PPSPFHHLDF SHSLSFGGRE
DEGPPGYPEP LAPEHGSPFP SLSKKDLDLM LLDDSLLPLA SDPLLSTMSP EASKASSRRS
SFSMEEGDVL
//
