ID A0A2K6CSF7_MACNE Unreviewed; 770 AA.
AC A0A2K6CSF7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=CCR4-NOT transcription complex subunit 3 {ECO:0000313|Ensembl:ENSMNEP00000026626.1};
GN Name=CNOT3 {ECO:0000313|Ensembl:ENSMNEP00000026626.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000026626.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000026626.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. May be involved in
CC metabolic regulation; may be involved in recruitment of the CCR4-NOT
CC complex to deadenylation target mRNAs involved in energy metabolism.
CC Involved in mitotic progression and regulation of the spindle assembly
CC checkpoint by regulating the stability of MAD1L1 mRNA. Can repress
CC transcription and may link the CCR4-NOT complex to transcriptional
CC regulation; the repressive function may involve histone deacetylases.
CC Involved in the maintenance of embryonic stem (ES) cell identity.
CC {ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|PIRNR:PIRNR005290}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
CC Note=NANOS2 promotes its localization to P-body.
CC {ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682, ECO:0000256|PIRNR:PIRNR005290}.
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DR AlphaFoldDB; A0A2K6CSF7; -.
DR STRING; 9545.ENSMNEP00000026626; -.
DR Ensembl; ENSMNET00000050912.1; ENSMNEP00000026626.1; ENSMNEG00000036750.1.
DR GeneTree; ENSGT00390000014743; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036750; Expressed in multicellular organism and 13 other cell types or tissues.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:UniProtKB-UniRule.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-UniRule.
DR GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005290};
KW Developmental protein {ECO:0000256|PIRNR:PIRNR005290};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005290};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR005290};
KW RNA-mediated gene silencing {ECO:0000256|PIRNR:PIRNR005290};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR005290};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR005290};
KW Translation regulation {ECO:0000256|PIRNR:PIRNR005290}.
FT DOMAIN 29..251
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 639..764
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 259..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 83596 MW; DCAECE57987A8E86 CRC64;
MCSLFGGLLF RYLPPGQDSH SLLPPWPGEI DRCLKKVSEG VEQFEDIWQK LHNAANANQK
EKYEADLKKE IKKLQRLRDQ IKTWVASNEI KDKRQLIDNR KLIETQMERF KVVERETKTK
AYSKEGLGLA QKVDPAQKEK EEVGQWLTNT IDTLNMQVDQ FESEVESLSV QTRKKKGDKD
KQDRIEGLKR HIEKHRYHVR MLETILRMLD NDSILVDAIR KIKDDVEYYV DSSQDPDFEE
NEFLYDDLDL EDIPQALVAT SPPSHSHMED EIFNQSSSTP TSTTSSSPIP PSPANCTTEN
SEDDKKRGRS TDSEVSQSPA KNGSKPVHSN QHPQSPAVPP TYPSGPPPAA SALSTTPGNN
GVPAPAAPPS ALGPKASPAP SHNSGTPAPY AQAVAPSATS GPSTTQPRPP SAQPGGGGGG
GGGGSGSNSN SSAGGGAGKQ NGATSYSSVV ADSPAEVALS SSGGNNASSQ ALGPPSGPHN
PPPSTSKEPS AAAPTGAGGV APGSGNNSGG PSLLVPLPVN PPSSPTPSFS DAKAAGALLN
GPPQFSTAPE IKAPEPLSSL KSMAERAAIS SGIEDPVPTL HLTERDIILS STSAPPASAQ
PPLQLSEVNI PLSLGVCPLG PVPLTKEQLY QQAMEEAAWH HMPHPSDSER IRQYLPRNPC
PTPPYHHQMP PPHSDTVEFY QRLSTETLFF IFYYLEGTKA QYLAAKALKK QSWRFHTKYM
MWFQRHKEPK TITDEFEQGT YIYFDYEKWG QRKKEGFTFE YRSLEDQDLQ
//
