ID A0A2K6CSW7_MACNE Unreviewed; 366 AA.
AC A0A2K6CSW7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Leupaxin {ECO:0000256|PIRNR:PIRNR037881};
GN Name=LPXN {ECO:0000313|Ensembl:ENSMNEP00000026745.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000026745.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000026745.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Transcriptional coactivator for androgen receptor (AR) and
CC serum response factor (SRF). Contributes to the regulation of cell
CC adhesion, spreading and cell migration and acts as a negative regulator
CC in integrin-mediated cell adhesion events. Suppresses the integrin-
CC induced tyrosine phosphorylation of paxillin (PXN).
CC {ECO:0000256|PIRNR:PIRNR037881}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246, ECO:0000256|PIRNR:PIRNR037881}.
CC Cytoplasm {ECO:0000256|PIRNR:PIRNR037881}. Nucleus
CC {ECO:0000256|PIRNR:PIRNR037881}. Cytoplasm, perinuclear region
CC {ECO:0000256|PIRNR:PIRNR037881}. Cell projection, podosome
CC {ECO:0000256|PIRNR:PIRNR037881}. Cell membrane
CC {ECO:0000256|PIRNR:PIRNR037881}.
CC -!- DOMAIN: The LIM domain 3 is critical for focal adhesion targeting and
CC the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM
CC domain 3 alone or both LIM domains 3 and 4 can mediate interaction with
CC AR. {ECO:0000256|PIRNR:PIRNR037881}.
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813, ECO:0000256|PIRNR:PIRNR037881}.
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DR AlphaFoldDB; A0A2K6CSW7; -.
DR Ensembl; ENSMNET00000051031.1; ENSMNEP00000026745.1; ENSMNEG00000036787.1.
DR GeneTree; ENSGT00940000160259; -.
DR OMA; QNGKTYC; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036787; Expressed in thymus and 8 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd09406; LIM1_Leupaxin; 1.
DR CDD; cd09410; LIM3_Leupaxin; 1.
DR CDD; cd09339; LIM4_Paxillin_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR017305; Tgfb1i1/Leupaxin/TGFB1I1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR PANTHER; PTHR24214:SF38; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF00412; LIM; 4.
DR PIRSF; PIRSF037881; Leupaxin; 1.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cell adhesion {ECO:0000256|PIRNR:PIRNR037881};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW ECO:0000256|PIRNR:PIRNR037881};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037881};
KW Cell projection {ECO:0000256|PIRNR:PIRNR037881};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037881};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR037881};
KW Membrane {ECO:0000256|PIRNR:PIRNR037881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037881};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|PIRNR:PIRNR037881};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR037881};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 130..189
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 190..247
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 248..307
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 308..366
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 366 AA; 41570 MW; 1286654B6565A5F0 CRC64;
MPYWRNWNAP PFRTVMNIPT QLLFPWISIP ERRVTLTRLQ RSFLFRITQV PCREAQEPKV
SPPPSKTSAA AQLDELMAHL TEMQAKVAVR ADAGKKHLPD KQDHKASLDS MLGGLEQELQ
DLGIATVPKG HCASCRKPIA GKVIHALGQS WHPEHFVCTH CKEEIGSSPF FERNGLAYCP
NDYHQLFSPR CAYCAAPILD KVLTAMNQTW HPEHFFCSHC GEVFGAEGFH EKDKKPYCRK
DFLAMFSPKC GGCNRPVLEN YLSAMDTVWH PECFVCGDCF TSFSTGSFFE LDGRPFCELH
YHHRRGTLCH GCGQPITGRC ISAMGHKFHP EHFVCAFCLT QLSKGIFREQ NDKTYCQPCF
NKLFPL
//
