ID A0A2K6CUQ0_MACNE Unreviewed; 839 AA.
AC A0A2K6CUQ0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Taste receptor type 1 member 2 {ECO:0000256|ARBA:ARBA00040704};
DE AltName: Full=Sweet taste receptor T1R2 {ECO:0000256|ARBA:ARBA00042616};
GN Name=TAS1R2 {ECO:0000313|Ensembl:ENSMNEP00000027399.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000027399.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000027399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners. {ECO:0000256|ARBA:ARBA00037659}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC {ECO:0000256|ARBA:ARBA00038699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR RefSeq; XP_011742099.1; XM_011743797.1.
DR AlphaFoldDB; A0A2K6CUQ0; -.
DR STRING; 9545.ENSMNEP00000027399; -.
DR Ensembl; ENSMNET00000051691.1; ENSMNEP00000027399.1; ENSMNEG00000037099.1.
DR GeneID; 105483125; -.
DR CTD; 80834; -.
DR GeneTree; ENSGT00940000156136; -.
DR OMA; STCLCRQ; -.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037099; Expressed in multicellular organism.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1903767; C:sweet taste receptor complex; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0033041; F:sweet taste receptor activity; IEA:Ensembl.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IEA:Ensembl.
DR CDD; cd15288; 7tmC_TAS1R2; 1.
DR CDD; cd06363; PBP1_taste_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF517; TASTE RECEPTOR TYPE 1 MEMBER 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..839
FT /note="Taste receptor type 1 member 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014439828"
FT TRANSMEM 567..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 565..823
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 839 AA; 95179 MW; 8544A40984A78CA1 CRC64;
MRPRATTICS LFFLLRVLAE PAKNSDFYLP GDYLLGGLFT LHANMKGIVH LDYLQVPMCK
EYETKVIGYN LMQAMRFAVE EINNDSSLLP DVLLGYEMVD VCYVSNNVQP VLYFLAQEDD
LLPIQENYSN YVPRVVAVIG PDNSDAVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL
LRTAPSADHH IEAMVQLMLH FRWNWIIVLV SGDTYGRDNG QLLGDRLARG DICIAFQETL
PTVQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYNFFNEVLR QNFTGAVWIA
SESWAIDPVL HNLTELRHMG TFLGITIQSV PIPGFSEFRV RDPQAGPPPL SRTSQRSTCN
QECDSCLNGT LSFNNVLRLS GERVVYSVYS AVYAVAHALH SFLGCDHGTC TKREVYPWQL
LKEIWKVNFT LLDHEISFDP QGDMALHLEI VQWQWGLSQN PFQSVASYYP LQRQLKKIQD
ISWHTINNTI PVSMCSKRCQ SGQKKKPVGI HICCFECIDC LPGTFLNQTE DEYECQACPS
NEWSHQSEAS CFKRRLAFLE WHEAPTIVVA LLAALGFLST LAILVIFWRH FQTPMVRSAG
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC FCRQALFPLC FTICISCIAV RSFQIVCVFK
MASRFPRAYR YWVRYQGPYV SMAFITVLKM VTVVIGMLAT GLNPTTRIDP DDPKIMIVSC
NPNYRNSLFF NTGLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM
SAYNGVLVTI MDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD
//