ID A0A2K6CVM3_MACNE Unreviewed; 713 AA.
AC A0A2K6CVM3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=UDP-N-acetylglucosamine transporter {ECO:0000256|ARBA:ARBA00040900};
DE AltName: Full=Golgi UDP-GlcNAc transporter {ECO:0000256|ARBA:ARBA00041527};
DE AltName: Full=Solute carrier family 35 member A3 {ECO:0000256|ARBA:ARBA00041936};
GN Name=MFSD14A {ECO:0000313|Ensembl:ENSMNEP00000027720.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000027720.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000027720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR AlphaFoldDB; A0A2K6CVM3; -.
DR SMR; A0A2K6CVM3; -.
DR STRING; 9545.ENSMNEP00000027720; -.
DR Ensembl; ENSMNET00000052013.1; ENSMNEP00000027720.1; ENSMNEG00000037178.1.
DR GeneTree; ENSGT00940000157395; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037178; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0030382; P:sperm mitochondrion organization; IEA:Ensembl.
DR GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR CDD; cd17387; MFS_MFSD14; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR NCBIfam; TIGR00803; nst; 1.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF36; UDP-N-ACETYLGLUCOSAMINE TRANSPORTER; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 259..676
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 689..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 77971 MW; A2569D16732C1D73 CRC64;
MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK
DSKCSLRALN RVLHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK
ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QLDSKELSAG SQFVGLMAVL
TACFSSGFAG VYFEKILKET KQSVWIRNIQ LGFFGSIFGL MGVYIYDGEL VSKNGFFQGY
NRLTWIVVVL QPQGIGSPSV YHAVIVIFLE FFAWGLLTAP TLVVLHETFP KHTFLMNGLI
QGVKGLLSFL SAPLIGALSD VWGRKSFLLL TVFFTCAPIP LMKISPWWYF AVISVSGVFA
VTFSVVFAYV ADITQEHERS MAYGLVSATF AASLVTSPAI GAYLGRVYGD SLVVVLATAI
ALLDICFILV AVPESLPEKM RPASWGAPIS WEQADPFASL KKVGQDSIVL LICITVFLSY
LPEAGQYSSF FLYLRQIMKF SPESVAAFIA VLGILSIIAQ TIVLSLLMRS IGNKNTILLG
LGFQILQLAW YGFGSEPWMM WAAGAVAAMS SITFPAVSAL VSRTADADQQ GVVQGMITGI
RGLCNGLGPA LYGFIFYIFH VELKELPITG TDLGTNTSPQ HHFEQNSIIP GPPFLFGACS
VLLALLVALF IPEHTNLSLR SSSWRKHCGS HSHPHSTQAP GEAKEPLLQD TNV
//
