ID A0A2K6CXX0_MACNE Unreviewed; 1707 AA.
AC A0A2K6CXX0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Kinesin family member 1A {ECO:0000313|Ensembl:ENSMNEP00000028504.1};
GN Name=KIF1A {ECO:0000313|Ensembl:ENSMNEP00000028504.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000028504.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000028504.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMNET00000052847.1; ENSMNEP00000028504.1; ENSMNEG00000036707.1.
DR GeneTree; ENSGT00940000156474; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000036707; Expressed in temporal lobe and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 5..352
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1592..1690
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 553..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1535..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 437..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 631..665
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1435..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1707 AA; 192443 MW; 3D9E9AE7DAD0DE81 CRC64;
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT
SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP
QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMVS GPNKKKKKTD
FIPYRDSVLT WLLRENLGGN SRTAMVAALS PADINYDETL STLRYADRAK QIRCNAVINE
DPNNKLIREL KDEVTRLRDL LYAQGLGDIT DTNTVPGGPK LTNALVGMSP SSSLSALSSR
AASVSSLHER ILFAPGSEEA IERLKETEKI IAELNETWEE KLRRTEAIRM EREALLAEMG
VAMREDGGTL GVFSPKKTPH LVNLNEDPLM SECLLYYIKD GVTRVGREDG ERRQDIVLSG
HFIKEEHCVF RSDSRGGSEG MATLPSPPAP TALGHPVPAS PALRNRIIMG KSHVFRFNHP
EQARQERERT PCAETPAEPV DWAFAQRELL EKQGIDMKQE MEQRLQELED QYRREREEAT
YLLEQQRLDY ESKLEALQKQ MDSRYYPEVN EEEEEPEDEV QWTERECELA LWAFRKWKWY
QFTSLRDLLW GNAIFLKEAN AISVELKKKV QFQFVLLTDT LYSPLPPDLL PPEAAKDRET
RPFPRTIVAV EVQDQKNGAT HYWTLEKLRQ RLDLMREMYD RAAEVPSSVI EDCDNVVTGG
DPFYDRFPWF RLVGRAFVYL SNLLYPVPLV HRVAIVSEKG EVKGFLRVAV QAISADEEAP
DYGSGVRQSG TAKISFDDQH FEKFQSESCP VVGMSRSGTS QEELRIVEGQ GQGADVGPSA
DEVNNNTCSA VPPEGLLLDS SEKAALDGPL DTALDHLRLG STFTFRVTVL QASSISAEYA
DIFCQFNFIH RHDEAFSTEP LKNTGRGPPL GFYHVQNIAV EVTKSFIEYI KSQPIVFEVF
GHYQQHPFPP LCKDVLSPLR PSRRHFPRVM PLSKPGRKVP ATKLSTLTRP CPGPCHCKYD
LLVYFEICEL EANGDYIPAV VDHRGGMPCM GTFLLHQGIQ RRITVTLLHE TGSHIRWKEV
RELVVGRIRN TPETDESLID PNILSLNILS SGYIHPAQDD RQFLDSDIPR TFYQFEAAWD
SSMHNSLLLN RVTPYREKIY MTLSAYIEME NCTQPAVITK DFCMVFYSRD AKLPASRSIR
NLFGSGSLRA SERDSHPGLG AGQAGLCLAA VLGPPGMQRR RRRVLDTSVA YVRGEENLAG
WRPRSDSLIL DHQWELEKLS LLQEVEKTRH YLLLREKLET TQRPVPEALS PAFSEDSESH
GSSSASSPLS TEGRPSPLEA PNERQRELAV KCLRLLTHTF NREYTHSHVC VSASESKLSE
MSVTLLRDPS MSPLGAATLT PSSTCPSLVE GRYGATDLRT PQPCSRPASP EPELLPEADS
KKLPSPARAT ETDKEPQRLL VPDIQEIRVS PIVSKKGYLH FLEPHTSGWA RRFVVVRRPY
AYMYNSDKDT VERFVLNLAT AQVEYSEDQQ AMLKTPNTFA VCTEHRGILL QAASDKDMHD
WLYAFNPLLA GTIRSKLSRR RSAQMRV
//
