ID A0A2K6CY01_MACNE Unreviewed; 561 AA.
AC A0A2K6CY01;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Centromere protein T {ECO:0000256|ARBA:ARBA00016401};
GN Name=CENPT {ECO:0000313|Ensembl:ENSMNEP00000028545.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000028545.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000028545.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-T/CNN1 family.
CC {ECO:0000256|ARBA:ARBA00010137}.
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DR RefSeq; XP_011756087.1; XM_011757785.1.
DR AlphaFoldDB; A0A2K6CY01; -.
DR STRING; 9545.ENSMNEP00000028545; -.
DR Ensembl; ENSMNET00000052891.1; ENSMNEP00000028545.1; ENSMNEG00000037705.1.
DR GeneID; 105491407; -.
DR KEGG; mni:105491407; -.
DR CTD; 80152; -.
DR GeneTree; ENSGT00390000003044; -.
DR OMA; YFQHLCN; -.
DR OrthoDB; 2919543at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037705; Expressed in bone marrow and 5 other cell types or tissues.
DR GO; GO:0000939; C:inner kinetochore; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR GO; GO:0051382; P:kinetochore assembly; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR028255; CENP-T.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR032373; CENP-T_N.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR46904; CENTROMERE PROTEIN T; 1.
DR PANTHER; PTHR46904:SF1; CENTROMERE PROTEIN T; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR Pfam; PF16171; CENP-T_N; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..415
FT /note="Centromere kinetochore component CENP-T N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16171"
FT DOMAIN 457..551
FT /note="CENP-T/Histone H4 histone fold"
FT /evidence="ECO:0000259|Pfam:PF15511"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 60552 MW; 46ADDAB10306FACA CRC64;
MADHNPDGDP TPRTLLRRVL DTADPRTPRR PRSARTGAQR ALLETASSRR LSGQTKTIAK
GRSRGARSIG RSAHVQARGH LEEQTPRTLL KNILLTAPES SILMPESVVK PVPAPQVVQP
SRRESSRSSL ELQLPELEPS TTLAPGLLAP GRRKQRLRLS MFQQGVDQGL PLSQEPQGNA
DASSLTSSLN LTFATPLQPQ SVQRPGLARR PPARRAVDVG AFLQDLRDTS LAPPNIVLED
TQPFSQPTVG SPNVYHSLPC TPHTGAEDAE QAAGRRTQSS GPGLQNNRPG KPAQFLAGEA
EEVDAFALGF LSTSSGVSGE DEVEPLHNGV EEAEKKMKEE GVSVSEMEAT GAQGPSRAEE
PEGHTQVTEA EGSQGTAEAE GPGASSGDED ASSRAASPES ASGTPESLQA RRHHQFPEPA
PPPGAAVLSS EPAEPLLVRC PPRPRTTGPR PRQDPHKAGL SHYVKLFSFF AKMPMERKAL
EMVEKCLDKY FQHLCDDLEV FAAHAGRKTV KPEDLELLMR RQGLVTDQVS LHVLVERHLP
LEYRQLLIPC AYSGNSVFPA Q
//
