ID   A0A2K6CYM4_MACNE        Unreviewed;       394 AA.
AC   A0A2K6CYM4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=GDNF family receptor alpha like {ECO:0000313|Ensembl:ENSMNEP00000028760.1};
GN   Name=GFRAL {ECO:0000313|Ensembl:ENSMNEP00000028760.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000028760.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000028760.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961}.
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DR   RefSeq; XP_011735855.1; XM_011737553.1.
DR   RefSeq; XP_011735856.1; XM_011737554.1.
DR   AlphaFoldDB; A0A2K6CYM4; -.
DR   STRING; 9545.ENSMNEP00000028760; -.
DR   Ensembl; ENSMNET00000053117.1; ENSMNEP00000028760.1; ENSMNEG00000037842.1.
DR   GeneID; 105479548; -.
DR   KEGG; mni:105479548; -.
DR   CTD; 389400; -.
DR   GeneTree; ENSGT00730000111274; -.
DR   OMA; NVIHSCR; -.
DR   OrthoDB; 3043164at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000037842; Expressed in bone marrow and 1 other cell type or tissue.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0016167; F:glial cell-derived neurotrophic factor receptor activity; IEA:Ensembl.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0002023; P:reduction of food intake in response to dietary excess; IEA:Ensembl.
DR   GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Ensembl.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   PANTHER; PTHR10269:SF1; GDNF FAMILY RECEPTOR ALPHA-LIKE; 1.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   Pfam; PF02351; GDNF; 2.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; GDNF receptor-like; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..394
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014450109"
FT   TRANSMEM        352..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..101
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          131..210
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          220..316
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
SQ   SEQUENCE   394 AA;  44557 MW;  9819F16B5FBF1E2D CRC64;
     MIVLIFLALG LSLENEYTSQ TNNCTYLREQ CLHDANGCKH AWRIMEDACN DSDPGDPCKM
     KNSSYCNLSI QYLVESNFRF KECLCTDDFY CTVNKLLGKE CVNKSDNMRE DKFKWNLTTH
     SHHGFKGMWS CLEVAEACVG DVVCNAQLAS YLKACSANGN PCDVKHCQAA IRFFYQNIPF
     NIAQMLAFCD CSQSDIPCQQ SKEALHSKPC ALNMVPPPTC LNVIRSCQND ELCRRHYRTF
     QSKCWQRVTR KCHEDENCIS ALSKQDLTCS GSDDCKAAYI DILGTVLQVQ CNCRTITQSE
     ESLCKIFQHM LHRKSCFNYP TLSNVKSMAL YTRKHTNKIT LTGFQSPFNG EVIYAAMCMT
     VTCGILLLVM VKLRTSRISS KARDPSLSQV PGEL
//