ID A0A2K6CYX5_MACNE Unreviewed; 651 AA.
AC A0A2K6CYX5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=TNF receptor associated protein 1 {ECO:0000313|Ensembl:ENSMNEP00000028862.1};
GN Name=TRAP1 {ECO:0000313|Ensembl:ENSMNEP00000028862.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000028862.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000028862.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR AlphaFoldDB; A0A2K6CYX5; -.
DR Ensembl; ENSMNET00000053228.1; ENSMNEP00000028862.1; ENSMNEG00000037882.1.
DR GeneTree; ENSGT01020000230401; -.
DR OMA; DHTQQNE; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037882; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528:SF44; HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 55..208
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 651 AA; 74301 MW; 9ABB6FA3C2F9FB64 CRC64;
MARELRALLL WGRRLRPLLR APALAAVPGG SISKHEFQAE TKKLLDVVAR SLYSEKEVFI
RELISNASDA LEKLRHKLVS DGQALPEMEI HLQTDAEKGT ITIQDTGIGM TQEELVSNLG
TIARSGSKAF LDTLQNQAEA SSKIIGQFGV GFYSAFMVAD RVEVYSRSAA PGSPGYRWLS
DGSGVFEIAE ASGVRTGTKI IIHLKSDCRE FASEARVRDV VAKYSNFVSF PLYLNGRRKN
TLQAIWMMDP KDISEWQHEE FYRYIAQAYD KPRYTLHYKT DAPLNIRSLF YVPDTKPSMF
DVSRELGSSI ALYSRKVLIQ TKATDILPKW LRFIRGVVDS EDIPLNLSRE LLQESMLIRK
LRDVLQQRLI KFFIDQSKKD AEKYAKFFED YGLFMREGIV TTTEQEVKED IAKLLRYESS
ALPAGQLTSL SEYASRMQAG TRNIYYLCAP NRHLAEHSPY YEAMKKKDTE VLFCYEQFDE
LTLLHLREFD KKQLISVETD IVVDHYKEEK FEDGSPAAER LSEEETEELM AWMRNVLGSR
VTNVKVTLRL DTHPAMVTVL EMGAARHFLR MQQLAKTQEE RAQLLQPTLE INPRHVLIKK
LNQLRASEPG LAQLLVDQIY ENAMIAAGLV DDPRAMVGRL NELLVKALER H
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