ID A0A2K6CZ59_MACNE Unreviewed; 1086 AA.
AC A0A2K6CZ59;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
GN Name=DLC1 {ECO:0000313|Ensembl:ENSMNEP00000028952.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000028952.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000028952.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6CZ59; -.
DR Ensembl; ENSMNET00000053321.1; ENSMNEP00000028952.1; ENSMNEG00000037830.1.
DR GeneTree; ENSGT00950000183061; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037830; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09591; SAM_DLC1; 1.
DR CDD; cd08908; START_STARD12-like; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 636..842
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 872..1057
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 114..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1086 AA; 122051 MW; 97BF3B31C8702E50 CRC64;
LLKEKPKQIE AKEACDWLRA TGFPQYAQLY EDFLFPIDIS LVKREHDFLD RDAIEALCRR
LNTLNKCAVM KLEISPHRKR SDDSDEDEPC AISGKWTFQR DSKRWSRLEE FDVFSPKQDP
VPGSPDDSHP KDGASPGGTL MDRGERQEVS SVRSLSSTGS LASHAPPSED AATPRTNSVI
SVCSSSNLAG NDDSFGSLPS PKELSSFSFS MKGHEKTAKS KTRSLLKRME SLKLKGSHHS
KHKAPSKLGL IISGPILQEG VDEEKLKQLN CVEISALNGN GVNVPMVRKR SVSNSTQTSS
SSSQSETSSA VSTPSPVTRT RSLSACNKRV GMYLEGFDPF NQSTFNNVME QNFKNRESYP
EDTVFYIPED HKPGTFPKAL TNGSFSPSGN NGSVNWRTGS FHGPGHISLR RENSSDNPKE
LKRRNSSSSM SSRLSIYDNV PGSILYSSSG DLADLENEDI FPELDDILYH VKGMQRIVNQ
WSEKFSDEGD SDSALDSVSP CPSSPKQIHL DVDNDRTTPS DLDSTGNSLN EPEEPSDIPE
RRDSGVGASL TRSNRHRLRW HSFQSSHRPS LNSVSLQINC QSVAQMNLLQ KYSLLKLTAL
LEKYTPSNKH GFSWAVPKFM KRIKVPDYKD RSVFGVPLTV NVQRTGQPLP QSIQQAMRYL
RNHCLDQVGL FRKSGVKSRI QALRQMNEGA VDCVNYEGQS AYDVADMLKQ YFRDLPEPLM
TNKLSETFLQ IYQYVPKDQR LQAIKAAIML LPDENREVLQ TLLYFLSDVT AAVKENQMTP
TNLAMCLAPS LFHLNTLKRE NSSPRVMQRK QSLGKPDQKD LNENLAATQG LAHMIAECKK
LFQVPEEMSR CRNSYTEQEL KPLTLEALGH LGNDDSADYQ HFLQDCVDGL FKEVKEKFKG
WVSYSTSKQA ELSYKKVSEG PPLRLWRSTI EVPAVPEEIL KRLLKEQHLW DVDLLDSKVI
EILDSQTEIY QYVQNSMAPH PARDYVVLRT WRTNLPKGAC ALLLTSVDHD RAPVVGVRVN
VLLSRYLIEP CGPGKSKLTY MCRADLRGHM PEWYTKSFGH LCAAEVVKIR DSFSNQNTET
KDTKSR
//
