ID A0A2K6CZ79_MACNE Unreviewed; 382 AA.
AC A0A2K6CZ79;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Recombination signal binding protein for immunoglobulin kappa J region {ECO:0000313|Ensembl:ENSMNEP00000028964.1};
GN Name=RBPJ {ECO:0000313|Ensembl:ENSMNEP00000028964.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000028964.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000028964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Su(H) family.
CC {ECO:0000256|ARBA:ARBA00009704}.
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DR AlphaFoldDB; A0A2K6CZ79; -.
DR Ensembl; ENSMNET00000053334.1; ENSMNEP00000028964.1; ENSMNEG00000037915.1.
DR GeneTree; ENSGT00390000005197; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037915; Expressed in lymph node and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.40.1450; LAG1, DNA binding domain; 1.
DR InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR InterPro; IPR036358; BTD_sf.
DR InterPro; IPR040159; CLS_fam.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR PANTHER; PTHR10665; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR PANTHER; PTHR10665:SF3; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR Pfam; PF09270; BTD; 1.
DR Pfam; PF09271; LAG1-DNAbind; 1.
DR SMART; SM01268; BTD; 1.
DR SMART; SM01267; LAG1_DNAbind; 1.
DR SUPFAM; SSF110217; DNA-binding protein LAG-1 (CSL); 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 33..164
FT /note="RBP-J/Cbf11/Cbf12 DNA binding"
FT /evidence="ECO:0000259|SMART:SM01267"
FT DOMAIN 165..314
FT /note="Beta-trefoil DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01268"
SQ SEQUENCE 382 AA; 43427 MW; D7E8E8BBBA804A62 CRC64;
MAWIKRKFGE RPPPKRLTRE AMRNYLKERG DQTVLILHAK VAQKSYGNEK RFFCPPPCVY
LMGSGWKKKK EQMERDGCSE QESQPCAFIG IGNSDQEMQQ LNLEGKNYCT AKTLYISDSD
KRKHFMLSVK MFYGNSDDIG VFLSKRIKVI SKPSKKKQSL KNADLCIASG TKVALFNRLR
SQTVSTRYLH VEGGNFHASS QQWGAFFIHL LDDDESEGEE FTVRDGYIHY GQTVKLVCSV
TGMALPRLII RKVDKQTALL DADDPVSQLH KCAFYLKDTE RMYLCLSQER IIQFQATPCP
KEPNKEMIND GASWTIISTD KAEYTFYEGM GPVLAPVTPV PVVESLQVWR EYALCRPRHF
CIPSRLEMGP ATSPGSSNFG PK
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