ID A0A2K6CZD6_MACNE Unreviewed; 2068 AA.
AC A0A2K6CZD6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Rho guanine nucleotide exchange factor 17 {ECO:0000313|Ensembl:ENSMNEP00000029020.1};
GN Name=ARHGEF17 {ECO:0000313|Ensembl:ENSMNEP00000029020.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000029020.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000029020.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011717319.1; XM_011719017.1.
DR STRING; 9545.ENSMNEP00000029020; -.
DR Ensembl; ENSMNET00000053392.1; ENSMNEP00000029020.1; ENSMNEG00000037963.1.
DR GeneID; 105468717; -.
DR KEGG; mni:105468717; -.
DR CTD; 9828; -.
DR GeneTree; ENSGT00940000153798; -.
DR OMA; IPQRHRT; -.
DR OrthoDB; 2917131at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000037963; Expressed in heart and 9 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1071..1259
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 20..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1569..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1623..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1995..2028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2041..2060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2007..2022
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2044..2058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2068 AA; 222163 MW; 032B307372D13B7E CRC64;
MADGAPRPPL YRSVSFKLLE RWSGGPGPRE EDTDTPGLRR RASCRPTTAA PGQPSRRVSK
LASGPPAAPA QPRPLRSLSP SVRQLSRRFD APRLDYGSAG ARDGGVFPAA AEEAAEGPAR
GAWPSVTEMR KLFGGPGSRR PSADSESPGT PSPDGAAWEP PARESRQPPT PPPRTCFPLV
GLRSARPLTG PGIEGRLRRQ QQQQQQQQER ALCPADGLHS WHIFSQPQAG ARASCSSSSS
IASSYRVSRS CAASSSEEEE EGPPQPPGAQ SPAYHGGHSS GSDDDRDGEG GHRWGGRPRL
RPGSSLLDQD CRPDSDGLNL SSMDSAGGAR SPEPPASPRA PGEEGLREWG SGSPPCVPGP
QEGLRPMSDS VGGALRVAKV SFPSYLASPA GSCGSSRYSS TETLKDDDLW SSRGSGGWGV
YRSPSFGAGE GLLRSQARTR AKGPGGTSRA LRDGGFEPEK SRQRKSLSNP DIASETLTLL
SFLRSDLSEL RVRKPGGSPG DRVSSPLDGR DSPSAGGSMG QLEPVSIPAP ASPGTRPTLK
DLTATLRRAK SFTCSEKPMA RRLPRTSALK PSSSELLLAG PSAEEDPLPL IVQDQYVQEA
RQVFEKIQRM GAQQDDGSDA PPESPDWARD VTRGQRSQEE LSGPESSLTD EGIGADPEPP
VAVFCGLGTT GMWRPLSSSS AQTNHRSPGT EDSLGGWALV SPEIPSTPGA LRRRRKVPPS
GSGGSELSNG EAGEAYRSLS DPIPQCHRAA TSEEPTGFSV DSNLLGSLSP KTGLPATSAM
DEGLTSGHSD WSVGSEESKG YQEVIQSIVQ GPGTLGRVVD DRVAGKAPKK KSLSDPSRRG
ELAGPGFQGP GGEPIREVEP VLPPSSSEPI LVEQRAEPEE PGAARSRAQS ERALPEALPP
PATAHQNFHL DPKLADILSP RLIRRGSKKR PARSSHQELG RDEGSQDQIG GLSRARPSSK
HVRHASVPAT FMPIVVPEPP TSVGPPVAVP EPIGFPARAH PTLQAPSLED VTKQYMLNLH
SGEVPAPVPV DMPCLPLAAL PSAETKPPEA ARPPHEPAPA SKCCSKPQVD MRKHVAMTLL
DTEQSYVESL RTLMQGYMQP LKQPENSVLC DPALVDEIFD QIPELLEHHE QFLEQVRHCM
HTWHAQQKVG ALLVQSFSKD VLVNIYSAYI DNFLNAKDAV RVAKEARPAF LKFLEQSMRE
NKEKQALSDL MIKPVQRIPR YELLVKDLLK HTPEDHPDHP LLLEAQRNIK QVAERINKGV
RSAEEAERHA RVLQEIEAHI EGMEDLQAPL RRFLRQEMVV EVKAISGKKD RSLFLFTDLI
VCTTLKRKSG SLRRSSMSLY TAASVIDTAS KYKMLWKLPL EDTDIIKGAS QATNRENIQK
AISRLDEDLT TLGQMSKLSE SLGFPHQSLD DALRDLSAAM HRDLSEKQAL CYALSFPPTK
LELCTTRPEG TDSYIFEFPH PDARLGFEQA FDEAKRKLAS SKSCLDPEFL KAIPIMKTRS
GMQFSCAAPT LNSCPEPSPE VWVCNSDGYV GQVCLLSLRA EPDVEACIAV CSARILCIGA
VPGLQRRCHR EPPPSLRSPS ETAPEPAGPE LDVEAAADEE AATLAEPGPQ PCLHISIAGS
GLEMTPGLAE GDPRPELVPF DSDSDDESSP SPSGTLQSQA SRSTISSSFG NEETPSSKEA
TAETTSSEEE QEPGFLPLSG SFGPGGPCST SPMDGRALRR SSRGSFTRGS LEDLLSVDPE
AYQSSVWLGT EDGCVHVYQS SDSIRDRRNS MKLQHAASVT CILYLNNQVF VSLANGDLVV
YQREAGHFWD PQNFKSVTLG AQGSPITKMV SVGGRLWCGC QNRVLVLSPD TLQLEHTFYV
GQDSSRSVAC MVDSSLGVWV TLKGSAHVCL YHPDTFEQLA EVDVTPPVHR MLAGSDAIIR
QHKAACLRIT ALLVCEELLW VGTSAGVVLT MPTSPSTVSC PRAPLSPTGL GQGHTGHVRF
LATVQLPDGF NLLCPTPPPA PDTGPEKLPS LEHRDSPRHR GPASARPKML VISGGDGYED
FRLSSGGGSS SETVGRDDST NHLLLWRV
//
