ID A0A2K6D098_MACNE Unreviewed; 1089 AA.
AC A0A2K6D098;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Myosin IB {ECO:0000313|Ensembl:ENSMNEP00000029342.1};
GN Name=MYO1B {ECO:0000313|Ensembl:ENSMNEP00000029342.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000029342.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000029342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; A0A2K6D098; -.
DR Ensembl; ENSMNET00000053740.1; ENSMNEP00000029342.1; ENSMNEG00000038028.1.
DR GeneTree; ENSGT00940000155752; -.
DR OMA; PLYGNEY; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038028; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF277; UNCONVENTIONAL MYOSIN-IB; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 26..712
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 905..1089
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 589..611
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 119..126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1089 AA; 126206 MW; 9BBEFAEA00738527 CRC64;
MPPTPTSFLE TMAKMEVKTS LLDNMIGVGD MVLLEPLNEE TFINNLKKRF DHSEIYTYIG
SVVISVNPYR SLPIYSPEKV EEYRNRNFYE LSPHIFALSD EAYRSLRDQD KDQCILITGE
SGAGKTEASK LVMSYVAAVC GKGAEVNQVK EQLLQSNPVL EAFGNAKTVR NDNSSRFGKY
MDIEFDFKGD PLGGVISNFL VKKFRILKHP RGERNFHVFY QLLSGASEEL LNKLKLERDF
SRYNYLSLDS AKVNGVDDAA NFRTVRNAMQ IVGFMDHEAE SVLAVVAAVL KLGNIEFKPE
SRVNGLDESK IKDKNELKEI CELTGIDQSV LERAFSFRTV EAKQEKVSTT LNVAQAYYAR
DALAKNLYSR LFSWLVNRIN ESIKAQTKVR KKVMGVLDIY GFEIFEDNSF EQFIINYCNE
KLQQIFIELT LKEEQEEYIR EDIEWTHIDY FNNAIICDLI ENNTNGILAM LDEECLRPGT
VTDETFLEKL NQVCATHQHF ESRMSKCSRF LNDTSLPHSC FRIQHYAGKV LYQVEGFVDK
NNDLLYRDLS QAMWKASHAL IKSLFPEGNP AKINLKRPPT AGSQFKASVA TLMKNLQTKN
PNYIRCIKPN DKKAAHIFTE ALVCHQIRYL GLLENVRVRR AGYAFRQAYE PCLERYKMLC
KQTWPHWKGP ARSGVEVLFN ELEIPVEEYS FGRSKIFIRN PRTLFKLEDL RKQRLEDLAT
LIQKIYRGWK CRTHFLLMKK SQIVIAAWYR RYAQQKRYQQ TKSSALVIQS YIRGWKARKI
LRELKHQKRC KEAVTTIAAY WHGTQVRREY RKFFRANAGK KIYEFTLQRI VQKYFLEMKN
KMPSLSPIDK NWPSRPYLFL DSTHKELKRI FHLWRCKKYR DQFTDQQKLI YEEKLEASEL
FKDKKALYPS SVGQPFQGAY LEINKNPKYK KLKDAIEEKI IIAEVVNKIN RANGKSTSRI
FLLTNNNLLL ADQKSGQIKS EVPLVDVTKV SMSSQNDGFF AVHLKEGSEA ASKGDFLFSS
DHLIEMATKL YRTTLSQTKQ KLNIEISDEF LVQFRQDKVC VKFIQGNQKN GSVPTCKRKN
NRLLEVAVP
//
