ID A0A2K6D0E8_MACNE Unreviewed; 386 AA.
AC A0A2K6D0E8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=N-terminal EF-hand calcium binding protein 2 {ECO:0000313|Ensembl:ENSMNEP00000029392.1};
GN Name=NECAB2 {ECO:0000313|Ensembl:ENSMNEP00000029392.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000029392.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000029392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011765647.1; XM_011767345.1.
DR AlphaFoldDB; A0A2K6D0E8; -.
DR STRING; 9545.ENSMNEP00000029392; -.
DR Ensembl; ENSMNET00000053792.1; ENSMNEP00000029392.1; ENSMNEG00000038164.1.
DR GeneID; 105496762; -.
DR CTD; 54550; -.
DR GeneTree; ENSGT00950000183131; -.
DR OrthoDB; 2900383at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038164; Expressed in thymus and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0031687; F:A2A adenosine receptor binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031802; F:type 5 metabotropic glutamate receptor binding; IEA:Ensembl.
DR GO; GO:1904021; P:negative regulation of G protein-coupled receptor internalization; IEA:Ensembl.
DR GO; GO:0060168; P:positive regulation of adenosine receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:1900451; P:positive regulation of glutamate receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1905477; P:positive regulation of protein localization to membrane; IEA:Ensembl.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR007138; ABM_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039862; NECAB1/2/3.
DR PANTHER; PTHR12178; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12178:SF2; N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 2; 1.
DR Pfam; PF03992; ABM; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51725; ABM; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 60..95
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 96..129
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 286..374
FT /note="ABM"
FT /evidence="ECO:0000259|PROSITE:PS51725"
FT COILED 174..201
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 386 AA; 43092 MW; ECBEB0E438EF0A43 CRC64;
MCERAARLCR AGAHRLLREP PQQGRALGGL LRWVGARMGE PREPLAPAVP ADPGPASPRG
GTAVILDIFR RADKNDDGKL SLEEFQLFFA DGVLSEKELE DLFHTIDSDN TNHVDTKELC
DYFVDHMGDY EDVLASLETL NHSVLKAMGY TKKVYEGGSN VDQFVTRFLL KETANQIQSL
LSSVESAVEA IEEQTSQLRQ NHSKPSHGVA QTWYGSPTRA SAPNHKLMAV EQGKGLPSAT
EDAKEEGLEA QISRLAELIG RLESKALWFD LQQRLSDEDG TNMHLQLVRQ EMAVCPEQLS
EFLDSLRPYL RGTAGARSCF HITAVRLSDG FTFVIYEFWE TEEAWKRHLQ SPVCKAFRHV
KVDTLSQPEA LSRISVPAVW CTVGRD
//
