ID A0A2K6D1S7_MACNE Unreviewed; 554 AA.
AC A0A2K6D1S7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Syntrophin alpha 1 {ECO:0000313|Ensembl:ENSMNEP00000029870.1};
GN Name=SNTA1 {ECO:0000313|Ensembl:ENSMNEP00000029870.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000029870.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000029870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the syntrophin family.
CC {ECO:0000256|ARBA:ARBA00010798}.
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DR AlphaFoldDB; A0A2K6D1S7; -.
DR STRING; 9545.ENSMNEP00000029870; -.
DR Ensembl; ENSMNET00000054284.1; ENSMNEP00000029870.1; ENSMNEG00000038405.1.
DR GeneTree; ENSGT00950000182863; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038405; Expressed in heart and 4 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0050998; F:nitric-oxide synthase binding; IEA:Ensembl.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:Ensembl.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:1902083; P:negative regulation of peptidyl-cysteine S-nitrosylation; IEA:Ensembl.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR GO; GO:1902305; P:regulation of sodium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0003117; P:regulation of vasoconstriction by circulating norepinephrine; IEA:Ensembl.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01258; PHsplit_syntrophin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR041428; PHsplit_syntrophin.
DR InterPro; IPR015482; Syntrophin.
DR PANTHER; PTHR10554:SF6; ALPHA-1-SYNTROPHIN; 1.
DR PANTHER; PTHR10554; SYNTROPHIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF18012; PH_17; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 6..269
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 87..170
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 364..450
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 58975 MW; 108BF802D14A58AB CRC64;
MASGRRAPRT GLLELRAGAG SGTGGERWQR VLLSLAEDVL TVSPADGDPG PESGAPREPE
PAQLNGAAEP GARAPQLPEA LLLQRRRVTV RKADAGGLGI SIKGGRENKM PILISKIFKG
LAADQTEALY VGDAILSVNG EDLSSATHDE AVQALKKTGK EVVLEVKYMK DVSPYFKNSA
GGTSVGWDSP PASPLQRQPS SPGPTPQNLS EAKHVSLKMA YVSKRCTPTD PEPRYLEICS
AEGQDTLFLR AKDEASARSW ASAIQAQVNA LMLRVKDELQ ALLAATSTAA SQDIKQIGWL
TEQVPAGPGT YPSLSSAPLE LALFPVPRLP CPTLALCPLF PHPSLLLFCP LQLPSGGTAP
TLALLTEKEL LLYSSLPETR EALSRPVRTA PLIATRLVHS GPSKGSVPYD AELSFALRTG
TRHGVDTHLF SVESPQELAA WTRQLVDGCH RAAEGVQEVS TACTWNGRPC SLSVHIDKGF
TLWAAEPGAA RAVLLRQPFE KLQMSSDDGA SLLFLDFGGA EGEIQLDLHS CPKTIVFIIH
SFLSAKVTRL GLLA
//
