ID A0A2K6D2A1_MACNE Unreviewed; 548 AA.
AC A0A2K6D2A1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor {ECO:0000313|Ensembl:ENSMNEP00000030039.1};
GN Name=NF2 {ECO:0000313|Ensembl:ENSMNEP00000030039.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000030039.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000030039.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A2K6D2A1; -.
DR Ensembl; ENSMNET00000054454.1; ENSMNEP00000030039.1; ENSMNEG00000038448.1.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038448; Expressed in temporal lobe and 12 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR23281:SF23; MERLIN; 1.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR PIRSF; PIRSF002305; ERM; 2.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..269
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 519..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 271..436
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 476..517
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 548 AA; 64006 MW; D5425B35515C10EE CRC64;
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEVL DHDVPKEEPV TFHFLAKFYP
ENAEEELVQE ITQHLFFLQV KKQILDEKIY CPPEASVLLA SYAVQAKYGD YDPSVHKRGF
LAQEELLPKR VINLYQMTPE MWEERITAWY AEHRGRARDE AEMEYLKIAQ DLEMYGVNYF
AIRNKKGTEL LLGVDALGLH IYDPENRLTP KISFPWNEIR NISYSDKEFT IKPLDKKIDV
FKFNSSKLRV NKLILQLCIG NHDLFMRRRK ADSLEVQQMK AQAREEKARK QMERQRLARE
KQMREEAERT RDELERRLLQ MKEEATMANE ALMRSEETAD LLAEKAQITE EEAKLLAQKA
AEAEQEMQRI KATAIRTEEE KRLMEQKVLE AEVLALKMAE ESERRAKEAD QLKQDLQEAR
EAERRAKQKL LEIATKPTYP PMNPIPAPLP PDIPSFNLIG DSLSFDFKDT DMKRLSMEIE
KEKVEYMEKS KHLQEQLNEL KTEIEALKLK ERETALDILH NENSDRGGSS KHNTIKKPQA
QGRRPICI
//
