ID A0A2K6D3D1_MACNE Unreviewed; 133 AA.
AC A0A2K6D3D1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Interleukin-7 {ECO:0000256|ARBA:ARBA00019460, ECO:0000256|PIRNR:PIRNR001942};
DE Short=IL-7 {ECO:0000256|PIRNR:PIRNR001942};
GN Name=IL7 {ECO:0000313|Ensembl:ENSMNEP00000030423.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000030423.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000030423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Hematopoietic cytokine that plays an essential role in the
CC development, expansion, and survival of naive and memory T-cells and B-
CC cells thereby regulating the number of mature lymphocytes and
CC maintaining lymphoid homeostasis. {ECO:0000256|PIRNR:PIRNR001942}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001942}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC {ECO:0000256|ARBA:ARBA00007621, ECO:0000256|PIRNR:PIRNR001942}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6D3D1; -.
DR Ensembl; ENSMNET00000054840.1; ENSMNEP00000030423.1; ENSMNEG00000038636.1.
DR GeneTree; ENSGT00390000004451; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038636; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.50; -; 2.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR038325; IL7_sf.
DR PANTHER; PTHR48404; INTERLEUKIN-7; 1.
DR PANTHER; PTHR48404:SF1; INTERLEUKIN-7; 1.
DR Pfam; PF01415; IL7; 2.
DR PIRSF; PIRSF001942; IL-7; 2.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR001942};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001942-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001942};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001942};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..133
FT /note="Interleukin-7"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014386773"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 27..122
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
FT DISULFID 59..110
FT /evidence="ECO:0000256|PIRSR:PIRSR001942-1"
SQ SEQUENCE 133 AA; 15246 MW; 37FB02CD3D86049F CRC64;
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD SMKEIGSNCL
NNEFNFFKRH LCDDNKVKGR KPAALGEPQP TKSLEENKSL KEQKKLNDSC FLKRLLQKIK
TCWNKILMGT KEH
//
