ID A0A2K6D5J5_MACNE Unreviewed; 551 AA.
AC A0A2K6D5J5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 {ECO:0000313|Ensembl:ENSMNEP00000031207.1};
GN Name=ARHGEF7 {ECO:0000313|Ensembl:ENSMNEP00000031207.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000031207.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000031207.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6D5J5; -.
DR Ensembl; ENSMNET00000055631.1; ENSMNEP00000031207.1; ENSMNEG00000038979.1.
DR GeneTree; ENSGT00940000155360; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038979; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 15..199
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 221..326
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 330..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 165..220
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 330..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 62035 MW; 7E6A06D3B8D64FBF CRC64;
MGSCSSQSMQ KTRRGRKVVL QNILETENEY SKELQTVLST YLRPLQTSEK LSSANISYLM
GNLEEICSFQ QMLVQSLEEC TKLPEAQQRV GGCFLNLMPQ MKALYLTYCA NHPSAVNPPL
PLIANHNEEL GEFMETKGAS SPGILVLTTG LSKPFMRLDK YPTLLKELER HMEDYHTDRQ
DIQKSMAAFK NLSAQCQEVR KRKELELQIL TESIRNWEGD DIKTLGNVTY MSQVLIQCAG
SEEKNERYLL LFPNVLLMLS ASPRMSGFIY QGKLPTTGMT ITKLEDSENH RNAFEISGSM
IERILVSCNN QQDLQEWVDH LQKQTKVTSV GNPTIKPHSV PSHTLPSHPV TPSSKHADSK
PAPLTPAYHT LPHPSHHGTP HTTINWGPLE PPKTPKPWSL SCLRPAPPLR PSAALCYKED
LSKSPKTMKK LLPKRKPERK PSDEEFASRK STAALEEDAQ ILKVIEAYCT SAKTRQTLNS
TWQGTDLMHN HVLADDDQPS LDSLGRRSSL SRLEPSDLSE DSDYDSIWTA HSYRMGSTSR
KSCCSYISHQ N
//
