ID A0A2K6D5S1_MACNE Unreviewed; 3324 AA.
AC A0A2K6D5S1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Laminin subunit alpha 3 {ECO:0000313|Ensembl:ENSMNEP00000031250.1};
GN Name=LAMA3 {ECO:0000313|Ensembl:ENSMNEP00000031250.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000031250.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000031250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR Ensembl; ENSMNET00000055674.1; ENSMNEP00000031250.1; ENSMNEG00000038755.1.
DR GeneTree; ENSGT00940000155638; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038755; Expressed in colon and 11 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 13.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF285; LAMININ SUBUNIT ALPHA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 11.
DR Pfam; PF02210; Laminin_G_2; 5.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 8.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..3324
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014399336"
FT DOMAIN 43..298
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 426..469
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 491..535
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 536..588
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 631..683
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1266..1311
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1356..1404
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1405..1455
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1476..1653
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1687..1733
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2381..2582
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2589..2751
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2758..2918
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2977..3141
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3148..3321
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1844..1906
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2012..2053
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2089..2160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2316..2374
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 445..454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 491..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 511..520
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 536..548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 538..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 557..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1266..1278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1268..1285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1287..1296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1380..1389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1405..1417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1407..1424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1426..1435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1706..1715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3324 AA; 365837 MW; EE2E53A0953BD003 CRC64;
MAAAARPRGR APGPVLPPTP LLLLVLQLLP AWGATARDPR AAAGLSLHPP YFNLAEAARI
WATATCGERG PSERRPRPEL YCKLVGGPTA PGSGHTIQGQ FCDYCNSEDP RKAHPVTNAI
DGSERWWQSP PLSSGTQYNR VNLTLDLGQL FHVAYILIKF ANSPRPDLWV LERSVDFGST
YSPWQYFAHS KVDCLKEFGR EANMAVTRDD DVLCVTEYSR IVPLENGEVV VSLINGRPGA
KNFTFSHTLR EFTKATNIRL RFLRTNTLLG HLISKAQRDP TVTRRYYYSI KDISIGGRCV
CNGHAEVCNA NNPEKLFRCQ CQHHTCGETC DRCCTGYNQR RWQPAAWEQS HECEACNCHG
HASDCYYDSD VERQQASLNT QSIYAGGGVC INCQHNTAGV NCEQCAKGYY RPYGVPVDAP
DGCIPCSCDP EHADGCEQGS GRCHCKPNFH GDNCEKCAVG YYNFPFCLKI PIFPVSTPSP
EDPVAGDIRG CDCNPEGVLP EICDAHGRCL CRPGVEGPRC DTCRSGFYSF PICQACLCSA
LGSYQMPCSS VTGQCECRPG VTGQRCDRCL SGAYDFPHCQ GSSSACDPAG TIDSNLGSCP
CKLHVEGPTC SICKPLYWNL DKENPNGCSE CQCHKAGTVS GTGECRQGDG DCHCKSHVGG
DSCDTCEDGY FALEKSNYFG CQGCQCDIGG ALSSVCSGPS GVCQCREHVV GKACQRPENN
YYFPDLHHMK YEIEDGSTPN GRDLRFGFDP LAFPGFSWRG YAQMTSVQND VRITLNVGKS
SGSLFHVILR YINPGTEAVS GHITIYPSWG AAQSKEIIFL PSKEPAFVTV PGNGFADPFS
ITPGIWVACI KAEGVLLDYL VLLPRDYYEA SVLQLPVTEP CAYAGPPQEN CLLYQHLPVT
RFPCTLACEA RRFLLDGEPR PVAVRQPTPA HPVMVDLSGR EVELHLRLRV PQVGRYVVVL
EYSTEAAQLF VADVNVKSPG SVLAGQVNIY SCKYSVLCRS AVIDHMSRIA VYELLADADI
QLKGHMARFL LHQVCIIPIE EFSAEYVRPQ VHCIASYRRF VNQSATCVSL AHETPPTALI
LDVVSGRPFP HLPQQSSPSV DVLPGVTLKA PQNQVTLRGR APHLGRYVFV IHFYQAAHPT
FPAQVSVDGG WPRAGSFRAS FCPHVLGCRD QVIAEGQIEF DISEPEVAAT VKVPEGKSLV
LVRVLMVPTE NYDYQILHKK SMDKSLEFIT NCGKNSFYID PQTASRFCKN SARSLVAFYH
KGALPCECHP AGATSPHCSP EGGQCPCRPN VIGRQCTRCA TGHYGFPHCK PCSCGLRLCE
EMTGQCRCPP RTVRPQCEVC ETHSFSFHPM AGCEGCNCSR RGTSEAAMLQ CDRDSGQCRC
KPRITGRQCD RCASGFYRFP ECVPCNCNRD GTEPGVCDPG TGACLCKENV EGTECNVCRE
GSFHLDPANP KGCTSCFCFG VNNQCHSAHK RRAKFVDMLG WCLETADRMH IPVSFNPGSN
SVVADLQELP ATVHSASWVA PASYLGDKVS SYGGYLTYQA KSFGLPSDMV LLEKKPDVQL
TGQHMSVIYE ETNTPRPDRL HHGRVQVVEG NFRHASSRAP VSREELMTVL SRLADMRIQG
LYFTETQRLT LSEVGLEEAS DTGSGRIAYA VEMCACPPAY AGDSCQGCSP GYYRDHKGLY
TGRCVPCNCN GHSNRCQDGS GICVNCQHNT AGEHCERCQE GYYGNAVHGS CRACPCPHTN
RFATGCVVNG GDVRCSCKAG YTGTQCCMEN PFLKCSLCIG LSFFQNPHPS LRRPGPTAPP
ASHLPLIVAP TDCDSCVMTL LNDLATMGEQ LRLVKSQLQG LSASAGLLEQ MRHMETQAKD
LRNQLLNYRS TISNHGSKIE GLERELTDLN QEFETLQEKA QVNSRKAQTL YNNVNRAIQS
AKELDMKIKT VIRNVHILLK QISGPDGEGN NVPSGGFSRE WAEAQRMMRE LRNRNFGKHL
REAEADKRES QLLLNRIRTW QKTHQGENNG LANSIRDSLN EYEAKLSDLR ARLQEAAARA
KQANGLNQEN ERALGAIQRQ VKEINSLQSD FTKYLTSADS SLLQTNIALQ LMEKSQKEYE
KLAASLNEAR QELSDKVREL SRSAGKTSLV EEAEKHAQSL QELAKQLEEI KRNASGDELV
RCAVDAATAY ENILNAIKAA EDAANRAASA SESALQTVIK EDLPRKAKTL SSNSDKLLNE
AKMTQKKLKQ EVSPALSNLQ QTLNIVTVQR EVIATNLTTL RDGLRGIQRG DIDAMISSAK
SMVRKANDIT DEVLDGLNPI QTDVERIKDT YGSTQNEDFK KALTDADNSV NKLTNKLPDL
WRKIESINQQ LLPLGNISDN MDRIRELIQQ ARDAASKVAV PMRFNGKSGV EVRLPNDLED
LKGYTSLSLF LQRPNSRENG GTENMFVMYL GNKDASRDYI GMAVVDGQLT CVYNLGDHET
ELQVDQILTE SETQEAVMDR VKFQRIYQFA RLNYTKGATS SKPEIPGVYD MDGRNSNTLL
NLDPENVVFY VGGYPPDFKL PSRLRFPPYK GCIELDDLNE NVLSLYNFKK TFNLNTTEVE
PCRRRKEESD KNYFEGTGYA RVPTQPHASI PTFGQTIQTT VDRGLLFFAE NRDRFISLNI
EDGKLMVRYK LNSEPPKERG VGDAINNGRD HSIQIKIGKV QKRMWINVDF QNTIIDGEVF
DFSTYYLGGI PIAIRERFNI STPAFRGCMK NLKKTSGVVR LNDTVGVTKK CSEDWKLVRS
ASFSRGGQLS FTNLGSPLTD HLQASFGFQT FQPSGILLSH QTRTSTLQVT LEDGHIELST
RDSGSPIFKS PQTYMDGLLH YVSVISDNSG LRLLIDDQPL RNNQRLNRIS SSQQSLRLGG
SNFEGCISNV FVQRLSLSPE VLDLASNSLK RDVSLGGCSL NKPPFLMLLQ GSTRFNKAKT
FRINQLLQDT PVASPRSMKV WQDACSPLPR TQANHGALQF GDIPTSHLLF KLPQELLKPR
SQFAVDVQTT SSRGLVFHTG TKNSFMALYL SKGRLVFALG TDGKKLRIKS KEKCNDGKWH
TVVFGHDGEK GRLVVDGLRA REGSLPGNST VSLRGPVYLG SPPSGKPKSL PTNSFVGCLK
NFQLDSKPLD TPSSSFGVSS CLGGPLEKGI YFSEEGGHVI LAHSVLLGPE FKLVFSIRPR
SLTGILIHIG SQPGKHLGVY LEAGKVTASM DSGAGGTSTS VTPKQSLCDG QWHSVAVTIK
QHILHLELDT DSSYTAGQIP FPPASTQEPL HLGGAPANLT TLRIPVWKSF FGCLRNIFVN
HIPVPVTEAL EVQGPVSLNG CPDH
//
