ID A0A2K6D5W9_MACNE Unreviewed; 825 AA.
AC A0A2K6D5W9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=BCAR3 adaptor protein, NSP family member {ECO:0000313|Ensembl:ENSMNEP00000031300.1};
GN Name=BCAR3 {ECO:0000313|Ensembl:ENSMNEP00000031300.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000031300.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000031300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011746043.1; XM_011747741.1.
DR RefSeq; XP_011746044.1; XM_011747742.1.
DR RefSeq; XP_011746045.1; XM_011747743.1.
DR RefSeq; XP_011746046.1; XM_011747744.1.
DR AlphaFoldDB; A0A2K6D5W9; -.
DR STRING; 9545.ENSMNEP00000031300; -.
DR Ensembl; ENSMNET00000055725.1; ENSMNEP00000031300.1; ENSMNEG00000039069.1.
DR GeneID; 105485405; -.
DR KEGG; mni:105485405; -.
DR CTD; 8412; -.
DR GeneTree; ENSGT00940000154130; -.
DR OrthoDB; 2953960at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000039069; Expressed in adult mammalian kidney and 11 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 154..253
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 548..818
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 45..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 92727 MW; 10456B4E97F139F1 CRC64;
MAAGKFASLP RNMPVNHQFP LASSMDLLSS KSPLAEHRPD AYQDVSIHGT LPRKKKGPPP
IRSCDDFSHM GTLPHSKSPW QNSPVTQDSI QESPWQDRHC ETFTFRDPHL LDPTLEYVKF
SKERHIMDRT PEKLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLVQR DGDFLVRDSL
SSPGNFVLTC QWKNLAQHFK INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP
ISQQSGAIIF QPINRTVPLR CLEERYGISP GQAREGSLTE GRPDVTKRLS LTMGGVQARE
QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP QSSGVDTSPC
PNSPVFRTGS EPTLSPAVVR RVCSDARAGE ALRGSDSQLC PKPPPKPCKV PFLKAPSSPS
AWLNSEASYC ELNPAFATGC GRGAKLPLCA QRSPTELLTA KQNGALGPRN SGINYLILDD
DDRERPWEPA AAQTEKGQWD KGEFVAPLLE TVSSFRPNDF ESKFLPPENK PLETAMVKRA
KELFTNNDPK VIAQHILSMD CRVARILEVS EEMRRNMGVS SGLELITLPH GHQLRLDITE
RHSTMAIGIA VYILGCTGTL EDRAATLSKI IQVAVELKDS MGDLYSFSAL MKALEMPQIT
RLEKTWTALR HQYTQTAILY EKQLKPFSKI LHEGRESTCV PPNNVSVPLL MPLVTLMERQ
AVTFEGTDMW EKNDQSCEIM LNHLATARLM AEATDSYRMN AERILAGFQP DEEMNEICKT
EFQMRLLWGS KGAQVNQAER YEKFNQILTA LSRKLEPPPV KQAEL
//
