ID A0A2K6D6J5_MACNE Unreviewed; 2556 AA.
AC A0A2K6D6J5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Talin 1 {ECO:0000313|Ensembl:ENSMNEP00000031542.1};
GN Name=TLN1 {ECO:0000313|Ensembl:ENSMNEP00000031542.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000031542.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000031542.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9545.ENSMNEP00000031542; -.
DR Ensembl; ENSMNET00000055969.1; ENSMNEP00000031542.1; ENSMNEG00000038684.1.
DR GeneTree; ENSGT00940000157006; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000038684; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0030274; F:LIM domain binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0017166; F:vinculin binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007044; P:cell-substrate junction assembly; IEA:Ensembl.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17171; FERM_F0_TLN1; 1.
DR CDD; cd17173; FERM_F1_TLN1; 1.
DR CDD; cd12150; talin-RS; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 4.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 8.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037438; Talin1/2-RS.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981; TALIN; 1.
DR PANTHER; PTHR19981:SF7; TALIN-1; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 2.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 5.
DR SUPFAM; SSF109885; I/LWEQ domain; 4.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 86..403
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2308..2548
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 1041..1094
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2478..2543
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2556 AA; 270970 MW; E590F5B31D9C2892 CRC64;
MVALSLKISI GNVVKTMQFE PSTMVYDACR IIRERIPEAP AGPPSDFGLF LSDDDPKKGI
WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG
ITNHDEYSLV RELMEEKKEE VTGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL
REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG
FQCQIQFGPH NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WNLTNIKRWA
ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML
EDSVSPKKST VLQQQYNRVG KVEHGSVALP AIMRSGASGP ENFQVGSMPP AQQQITSGQM
HRGHMPPLTS AQQALTGTIN SSMQAVQAAQ ATLDDFDTLP PLGQDAASKA WRKNKMDESK
HEIHSQVDAI TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED
EGGSGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE LLQQIGESDT
DPHFQICASG GAGVRSPPDS PTDVLMQLAK AVASAAAALV LKAKSVAQRT EDSGLQTQVI
AAATQCALST SQLVACTKVV APTISSPVCQ EQLVEAGRLV AKAVEGCVSA SQAATEDGQL
LRGVGAAATA VTQALNELLQ HVKAHATGAG PAGRYDQATD TILTVTENIF SSMGDAGEMV
RQARILAQAT SDLVNAIKAD AEGESDLENS RKLLSAAKIL ADATAKMVEA AKGAAAYPDS
EEQQQRLREA AEGLRMATNA AAQNAIKKKL VQRLEHAAKQ AAASATQTIA AAQHAASTPK
ASAGPQPLLV QSCKAVAEQI PLLVQGVRGS QAQPDSPSTQ LALIAASQSF LQPGGKMVAA
AKASVPTIQD QASAMQLSQC AKNLGTALAE LRTAAQKAQE ACGPLEMDSA LSLVQNLEKD
LQEVKAAARD GKLKPLPGET MEKCAQDLGN STKAVSSAIA QLLGEVAQGN ENYAGIAARD
VAGGLRSLAQ AARGVAALTS DPAVQAIVLD TASDVLDKAS SLIEEAKKAA GHPGDPESQQ
RLAQVAKAVT QALNRCVSCL PGQRDVDNAL RAVGDASKRL LSDSLPPSTG TFQEAQSRLN
EAAAGLNQAA TELVQASRGT PQDLARASGR FGQDFSTFLE AGVEMAGQAP SQEDRAQVVS
NLKGISMSSS KLLLAAKALS TDPAAPNLKS QLAAAARAVT DSINQLITMC TQQAPGQKEC
DNALRELETV RELLENPVQP INDMSYFGCL DSVMENSKVL GEAMTGISQN AKNGNLPEFG
EAISTASKAL CGFTEAAAQA AYLVGVSDPN SQAGQQGLVE PTQFARANQA IQMACHSLGE
PGCTQAQVLS AATIVAKHTS ALCNSCRLAS ARTANPTAKR QFVQSAKEVA NSTANLVKTI
KALDGAFTEE NRAQCRAATA PLLEAVDNLS AFASNPEFSS IPAQISPEGR AAMEPIVISA
KTMLESAGGL IQTARALAVN PRDPPSWSVL AGHSRTVSDS IKKLITSMRD KAPGQLECEA
AIAGLNSCLR DLDQASLAAV SQQLAPREGI SQEALHTQML TAVQEISHLI EPLANAARAE
ASQLGHKVSQ MAQYFEPLTL AAVGAASKTL SHPQQMALLD QTKTLAESAL QLLYTAKEAG
GNPKQAAHTQ EALEEAVQMM TEAVEDLTTT LNEAASAAGV VGGMVDSITQ AINQLDEGPM
GEPEGSFVDY QTTMVRTAKA IAVTVQEMVT KSNTSPEELG PLANQLTSDY GRLASEAKPA
AVAAENEEIG SHIKHRVQEL GHGCAALVTK AGALQCSPSD AYTKKDLCHP PPALSVSHVL
AALQAGNRGT QACITAASAV SGIIADLDTT IMFATAGTLN REGTETFADH REGILKTAKV
LVEDTKVLVQ NAAGSQEKLA QAAQSSVATI TRLTDVVKLG AASLGAEDPE TQVVLINAVK
DVAKALGDLI SATKAAAGKV GDDPAVWQLK NSAKVMVTNV TSLLKTVKAV EDEATKGTRA
LEATTEHIRQ ELAVFCSPEP PAKTSTPEDF IRMTKGITMA TAKAVAAGNS CRQEDVIATA
NLSRRAIADM LRACKEAAYH PEVAPDVRLR ALHYGRECAN GYLELLDHVL LTLQKPSPEL
KQQLTGHSKR VAGSVTELIQ AAEAMKGTEW VDPEDPTVIA ENELLGAAAA IEAAAKKLEQ
LKPRAKPKEA DESLNFEEQI LEAAKSIAAA TSALVKAASA AQRELVAQGK VGAIPANALD
DGQWSQGLIS AARMVAAATN NLCEAANAAV QGHASQEKLI SSAKQVAAST AQLLVACKVK
ADQDSEAMKR LQAAGNAVKR ASDNLVKAAQ KAAAFEEQEN ETVVVKEKMV GGIAQIIAAQ
EEMLRKEREL EEARKKLAQI RQQQYKFLPS ELRDEH
//
