ID A0A2K6D7G7_MACNE Unreviewed; 283 AA.
AC A0A2K6D7G7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Peflin {ECO:0000256|ARBA:ARBA00041025};
DE AltName: Full=PEF protein with a long N-terminal hydrophobic domain {ECO:0000256|ARBA:ARBA00041490};
DE AltName: Full=Penta-EF hand domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042606};
GN Name=PEF1 {ECO:0000313|Ensembl:ENSMNEP00000031855.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000031855.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000031855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00037873}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037873}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011761488.1; XM_011763186.1.
DR AlphaFoldDB; A0A2K6D7G7; -.
DR SMR; A0A2K6D7G7; -.
DR STRING; 9545.ENSMNEP00000031855; -.
DR Ensembl; ENSMNET00000056287.1; ENSMNEP00000031855.1; ENSMNEG00000039313.1.
DR GeneID; 105494616; -.
DR CTD; 553115; -.
DR GeneTree; ENSGT00940000155722; -.
DR OrthoDB; 318691at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000039313; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:Ensembl.
DR GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR GO; GO:0014029; P:neural crest formation; IEA:Ensembl.
DR GO; GO:1902527; P:positive regulation of protein monoubiquitination; IEA:Ensembl.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR CDD; cd16184; EFh_PEF_peflin; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46212; PEFLIN; 1.
DR PANTHER; PTHR46212:SF3; PEFLIN; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 113..148
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 180..215
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..63
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 30297 MW; A77D2BB76E24FD6E CRC64;
MASYPYRQGC PGAAGQAPGA PPGSYYPGPP NSGGQYGSGL PPGGYGGPAP GGPYGPPAGG
GPYGHPSPGM FPSGTPGGPY GGAAPGGPYG QPPLSSYGAQ QPGPYGQGGA PPNVDPEAYS
WFQSVDSDHS GYISMKELKQ ALVNCNWSSF NDETCLMMIN MFDKTKSGRI DVYGFSALWK
FIQQWKNLFQ QYDRDRSGSI SYTELQQALS QMGYNLSPQF TQLLVSRYCP RSANPAMQLD
RFIQVCTQLQ VLTEAFREKD TAVQGNIRLS FEDFVTMTAS RML
//
