ID A0A2K6D867_MACNE Unreviewed; 439 AA.
AC A0A2K6D867;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 {ECO:0000313|Ensembl:ENSMNEP00000032096.1};
GN Name=SPOCK1 {ECO:0000313|Ensembl:ENSMNEP00000032096.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000032096.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000032096.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_011714785.1; XM_011716483.1.
DR AlphaFoldDB; A0A2K6D867; -.
DR STRING; 9545.ENSMNEP00000032096; -.
DR Ensembl; ENSMNET00000056529.1; ENSMNEP00000032096.1; ENSMNEG00000039411.1.
DR GeneID; 105467102; -.
DR CTD; 6695; -.
DR GeneTree; ENSGT00940000158371; -.
DR OMA; GQESPKH; -.
DR OrthoDB; 4174283at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000039411; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR CDD; cd16237; EFh_SPARC_TICN1; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR PANTHER; PTHR13866:SF17; TESTICAN-1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..439
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014336195"
FT DOMAIN 130..181
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 310..376
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 397..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..439
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 348..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 439 AA; 49155 MW; D35171DCB8ACBC03 CRC64;
MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ YDRDKYWNRF
RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ DYQTALCVSR KHLLPRQKKG
NVAHKHWVGP SNLVKCKPCP VAQSAMVCGS DGHSYTSKCK LEFHACSTGK SLTTLCDGPC
PCLPEPEPPK HKAERSACTD KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS
ILPICKDSLG WMFNKLDMNY DLLLDHSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE
WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG STGQCWCVDK
YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLED ERELGPKDKE GKLRVHTRAV
TEDDEDEDDD KEDEVGYIW
//
