GenomeNet

Database: UniProt
Entry: A0A2K6D912_MACNE
LinkDB: A0A2K6D912_MACNE
Original site: A0A2K6D912_MACNE 
ID   A0A2K6D912_MACNE        Unreviewed;       875 AA.
AC   A0A2K6D912;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=formate--tetrahydrofolate ligase {ECO:0000256|ARBA:ARBA00012295};
DE            EC=6.3.4.3 {ECO:0000256|ARBA:ARBA00012295};
GN   Name=MTHFD1L {ECO:0000313|Ensembl:ENSMNEP00000032394.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000032394.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000032394.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the
CC       formate--tetrahydrofolate ligase family.
CC       {ECO:0000256|ARBA:ARBA00006985}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the tetrahydrofolate
CC       dehydrogenase/cyclohydrolase family. {ECO:0000256|ARBA:ARBA00005559}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6D912; -.
DR   Ensembl; ENSMNET00000056828.1; ENSMNEP00000032394.1; ENSMNEG00000039466.1.
DR   GeneTree; ENSGT00940000157477; -.
DR   OMA; CGEIMTM; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000039466; Expressed in cerebellum and 11 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   CDD; cd05212; NAD_bind_m-THF_DH_Cyclohyd_like; 1.
DR   Gene3D; 1.10.8.770; -; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR48099:SF12; MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01268; FTHFS; 2.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
PE   3: Inferred from homology;
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          20..112
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          116..236
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   875 AA;  95295 MW;  44730FFD5CAA433E CRC64;
     LRQRLALPQV IQNSKEVLSL LQEKNPAFKP VLAIIQAGDD NLMQEINQNL AEETGLNITH
     ICLPPDSSEA EIIDEILKIN EDTRVHGLAL QISENLFSNK VLNALKPEKD VDGVTDINLG
     KLVRGDAHEC FVSPVAKAAI ELLEKSVGVN LDGKKILVAG AHGSLEAALQ CLFQRKGSMT
     MSSQWKTPQL QRKLHEADIV VLGSRKPEEI PLTWIQPGIT VLNCSHDFLS GKVGCGSPRI
     HFGGLIEEDD VSLLAAALRI QNMVSSGRRW LREQQHRRWR LHCLKLQPLS PVPSDIEISR
     GQTPKVVDVL AKEIGLLADE IEIYGKSKAK VRLSVLERLK NQADGKYVLV AGITPTPLGE
     GKSTVTIGLV QALTAHLNVN SFACLRQPSQ GPTFGVKGGA AGGGYAQVIP MEEFNLHLTG
     DIHAITAANN LLAAAIDTRI LHENTQTDKA LYNRLVPLVN GVREFSEIQL ARLKKLGINK
     TDPSTLTEEE VSKFARLDIN PSTITWQRVL DTNDRFLRKI TIGQGNTEKG YSRQAQFDIA
     VASEIMAVLA LTDSLADMKA RLGRMVVASD KSGQPVTADD LGVTGALTVL MKDAIKPNLM
     QTLEGTPVFV HAGPFANIAH GNSSVLADKI ALKLVGEEGF VGKLLLLNLV VVTAGVPLKK
     EYTEENIQLV ADGCCNLQKQ IQIAQLFGVP VVVALNVFKT DTRAEIDLVC ELAKRAGAFD
     AVPCYHWSVG GKGSVDLARA VREAASKRSR FQFLYDVQVR SIVDKIRTIA QAVYGAKDIE
     LSPEAQAKID RYTQQGFGNL PICMAKTHLS LSHEPDKKGV PRDFILPISD VRASIGAGFI
     YPLVGTMSTM PGLPTRPCFY DIDLDTETEQ VKGLF
//
DBGET integrated database retrieval system