ID A0A2K6D941_MACNE Unreviewed; 518 AA.
AC A0A2K6D941;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
GN Name=INTS14 {ECO:0000313|Ensembl:ENSMNEP00000032438.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000032438.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000032438.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
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DR RefSeq; XP_011750669.1; XM_011752367.1.
DR RefSeq; XP_011750673.1; XM_011752371.1.
DR RefSeq; XP_011750676.1; XM_011752374.1.
DR RefSeq; XP_011750681.1; XM_011752379.1.
DR AlphaFoldDB; A0A2K6D941; -.
DR SMR; A0A2K6D941; -.
DR Ensembl; ENSMNET00000056872.1; ENSMNEP00000032438.1; ENSMNEG00000039516.1.
DR GeneID; 105488366; -.
DR KEGG; mni:105488366; -.
DR CTD; 81556; -.
DR GeneTree; ENSGT00390000009486; -.
DR OrthoDB; 3673014at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000039516; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 3..117
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 209..356
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 404..511
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
SQ SEQUENCE 518 AA; 57457 MW; 5B042BB2D61451BD CRC64;
MPTVVVMDVS LSMTRPVSIE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF TALVVFSSLW
ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ QEWGGAIPCQ VVLVTDGCLG
IGRGSLRHSL ATQNQRSESN RFPLPFPFPS KLYIMCMANL EELQSTDSLE CLERLIDLNN
GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTADVQVFPR PEPFVVDEEI
DPIPKVINTD LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGIT DDNEDENSAN
QIAGKIPNFC VLLHGSLKVE GMVAIVQLGP EWHGMLYSQA DSKKKSNLMM SLFEPGPEPL
PWLGKMAQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPDT AHPDAAFQLT
HAAQQLKLAS TGTSEYAAYD QNITPLHTDF SGSSTERI
//
