ID A0A2K6DCT1_MACNE Unreviewed; 488 AA.
AC A0A2K6DCT1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Eukaryotic translation initiation factor 2 alpha kinase 2 {ECO:0000313|Ensembl:ENSMNEP00000033718.1};
GN Name=EIF2AK2 {ECO:0000313|Ensembl:ENSMNEP00000033718.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000033718.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000033718.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6DCT1; -.
DR STRING; 9545.ENSMNEP00000033718; -.
DR Ensembl; ENSMNET00000058165.1; ENSMNEP00000033718.1; ENSMNEG00000040090.1.
DR GeneTree; ENSGT00940000160736; -.
DR OMA; LIQMEFC; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000040090; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:1902036; P:regulation of hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:1902033; P:regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0006412; P:translation; IEA:Ensembl.
DR CDD; cd19904; DSRM_EIF2AK2_rpt2; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044453; EIF2AK2_DSRM_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR PANTHER; PTHR11042:SF163; INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00358; DSRM; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 9..77
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 100..167
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 266..478
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 193..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 54127 MW; 09FF25EE99E4BBB8 CRC64;
MAGHLAPGFY MEELNKYRQK QGVSLSYQEL PNTGPPHDRR FTFQVVTDRR TFPEAEGRSK
KEAKNAAAKL AVDILNKESE AVSPFSLTTT SSSEGLSIGN YIGVVNRIAQ KKRLTVNYEQ
CTSGVHGPEG FHYKCKIGDK EYGIGTGSSK QEAKQLAAKL ALLEISEETS VKPDSMSSGS
FAATCDSQSN PLVNNSLASE SSAESDVSAD TSEINSKSGS LHISSLFTNG LRNNQRKAKR
SLAPTFDPPD MKGPKYTEDA RFSTDFKEIE FISVGGFGQV FKAKHRIDGK TYVIKRVKYN
SKKAEREVKA LAKLDHVNIV HYNGCWDGLD YDPEISAYEP ESPDFDPENQ KNSLPSNIFL
VDTKQIKIGD FGLATSLKND VKRTRNTGTL RYMSPEQISS QDYGKEVDLY ALGLILAELL
YVCDTASETS KLFQDLRGGT ISDVFDKREK ALLEKLLSKK PEDRPNTSEI LSTLTTWKKS
PEKKRHTC
//
