ID A0A2K6DD04_MACNE Unreviewed; 478 AA.
AC A0A2K6DD04;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Metaxin-1 {ECO:0000256|ARBA:ARBA00039748};
DE AltName: Full=Mitochondrial outer membrane import complex protein 1 {ECO:0000256|ARBA:ARBA00042095};
GN Name=MTX1 {ECO:0000313|Ensembl:ENSMNEP00000033801.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000033801.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000033801.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development. {ECO:0000256|ARBA:ARBA00037753}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR AlphaFoldDB; A0A2K6DD04; -.
DR STRING; 9545.ENSMNEP00000033801; -.
DR Ensembl; ENSMNET00000058248.1; ENSMNEP00000033801.1; ENSMNEG00000040125.1.
DR GeneTree; ENSGT00950000182919; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000040125; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0001401; C:SAM complex; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF34; METAXIN-1; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..296
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 335..398
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 52413 MW; 9D3BA531D1794FA6 CRC64;
MLLGGPPRSP RSGTSPKGPR SSTGHVQFGK SPQTWPRRTR PRSPEPAAPS GARGFTQPRR
RDSPKRAGRT ALSPLSRYVG HLWMGRRPPS PEARGPVPRS SAASRTRRSL ASPGTSPGPL
TATTGGAVVG GGSVQGRAGA HKEVFPGQRA GKMAAPMELF CWSGGWGLPS VDLDSLAVLT
YARFTGAPLK VHKISNPWRS PSGTLPALRT SHGEVISVPH KIITHLRKEK YNADYDLSAR
QGADTLAFMS LLEEKLLPVL VHTFWIDTKN YVEVTRKWYA EAMPFPLNFF LPGRMQRQYM
ERLELLSGEH MPEDEEELEK EPQGCWPGMG LYREARECLT LLSQRLGSQK FFFGDAPASL
DAFVFSYLAL LLQAKLPSGK LQAHLRGLHN LCAYCTHILS LYFPWDGAEV PPPRQTPAGP
ETEEEPYRRR NQILSVLAGL AAMVGYALLS GIVSIQRATP ARAPGTRALG MAEEDEEE
//