ID A0A2K6DD85_MACNE Unreviewed; 8813 AA.
AC A0A2K6DD85;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF {ECO:0000313|Ensembl:ENSMNEP00000033886.1};
GN Name=OBSCN {ECO:0000313|Ensembl:ENSMNEP00000033886.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000033886.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000033886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR STRING; 9545.ENSMNEP00000033886; -.
DR Ensembl; ENSMNET00000058333.1; ENSMNEP00000033886.1; ENSMNEG00000039875.1.
DR GeneTree; ENSGT00940000154756; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000039875; Expressed in skeletal muscle tissue and 5 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0031430; C:M band; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00096; Ig; 5.
DR CDD; cd20971; IgI_1_Titin-A168_like; 1.
DR CDD; cd13239; PH_Obscurin; 1.
DR CDD; cd12025; SH3_Obscurin_like; 1.
DR CDD; cd14107; STKc_obscurin_rpt1; 1.
DR CDD; cd14110; STKc_obscurin_rpt2; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 70.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR035526; Obscurin_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR35971:SF4; OBSCURIN; 1.
DR PANTHER; PTHR35971; SI:DKEY-31G6.6; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 61.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 66.
DR SMART; SM00408; IGc2; 56.
DR SMART; SM00406; IGv; 12.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 67.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 56.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 236..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..414
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 515..612
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 701..778
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 795..884
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 886..964
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 978..1056
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1070..1148
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1162..1252
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1254..1344
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1346..1432
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1438..1516
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1530..1616
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1622..1700
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1714..1792
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1806..1884
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1898..1976
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1992..2084
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2099..2170
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2172..2258
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2263..2347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2441..2525
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2531..2614
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2619..2710
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2798..2889
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2962..3060
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3156..3238
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3250..3329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3425..3497
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3514..3598
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3603..3686
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3691..3774
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3867..3950
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3955..4038
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4043..4126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4131..4214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4219..4302
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4307..4390
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4395..4478
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4483..4566
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4571..4654
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4659..4742
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4748..4831
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4836..4920
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4926..5018
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5106..5195
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5383..5479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5482..5553
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5757..5848
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5985..6074
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6119..6208
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6230..6326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6459..6526
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 6552..6736
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 6754..6863
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 6873..6956
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6967..7057
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7215..7303
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7326..7579
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 8310..8399
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 8404..8496
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 8519..8769
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 228..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5606..5642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5683..5718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6413..6455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7100..7140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7635..7720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7805..7912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7936..8035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8082..8122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8279..8300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6695..6722
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 5606..5633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6433..6449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7643..7659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7937..7951
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7975..7996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8015..8035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8279..8293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 7355
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 8813 AA; 962224 MW; CB56743CC95C4AA7 CRC64;
MDQSQFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDQQPV AAGARFRLAQ
DGDLYRLTIL DLALGDSGQY VCRARNAIGE AFAAVGLQVD AEAACAEQAP HFLLRPTSIH
VREGSEATFR CRVGGSPKPA VSWSKDGRRL GEPDGPRVRV EELGEASALR IRAARPRDGG
TYEVRAENPL GAASAAAALV VDSDAADTAS PPGTSTAALL AHLQRRREAM RAEGAPASPP
STGTRTCTVT EGKHARLSCY VTGEPKPETV WKKDGQLVTE GRRHVVYEDA QENFVLKILF
CKQSDRGLYT CTASNLVGQT YSSVLVVVRE PAVPFKKRLQ DLEVREKESA TFLCVVPQPS
TEAAWFKEET RLWASAKYGI EEEGTERRLT VRNVSADDDA VYICETQEGS RTVAELAVQG
NLLRKLPRKT AVRVGDTAMF CVELAVPVGP VRWVRNQEEV VTGGRVAISA EGTRHTLTIS
QCCLEDVGQV VFMAGDCRTS TQFCVSAPRK PPLQPPVDPV VKAKTESSVI LSWSPPPHGE
RPVTIDGYLV EKKKLGTYTW TRCHDAEWVA TPELTVADVA EEGDFQFRVS ALNSFGQSPY
LEFPGNVHLA PQLAVRTPLK AVQAVEGGEV TFSVDLTVAS AGEWFLDGQA LKTSSVFEIR
SDGTWHMLTI REVPASLHGA QLKFVANGIE SSIRMEVRAA PGLTVHKPPA AAAREVLARL
HEEAQLLAEL SDQAAAVTWL KDGRMLPPGP KYEVQASAGR RVLLVRDVAR EDAGLYECVS
CGGRIAYQLS VQGLPCFLHK DMAGSYVDAV AGGPVQFECE TSEAHVHVHW YKDGMELGRS
GERFLQEDVG TRHRLVAATV TRQDEGIYSC RVGEDSVDFR LRVSEPKAVF AKEQLARREI
QAEVGASATL SCEVAQDQTE VTWYKDGKKL SSSSKVHVEA VGCTRRLVVQ QAGQADAGEY
SCEARGQRIS FCLDVAEPKV VFAKEQLAHR KLQAEAGASA TLSCKVAQAQ TEVMWYKDGK
KLSSSSKVRM EATGCTRKLV VQQAGQADAG EYVCEAGGQR LSFHLDVKEP KVVFAKEQVA
HSEVQAEAGA RATLSCKVAQ AQTEVTWYKD GKKLSSSLKV HMEANGYRRR LVVQQVGKMD
AGDYSCEARG QRVFFHLHIT EPKMMFAKEQ SVHNEVWAEA GASAILSCEV AQAQMEVKWY
KDGKKLSSSS KVRMEIKGCT RRLVVQQVGK ADAGEYSCEA GGQRVSFQLH ITEPKAVFAK
EQSVHNEVQT EAGASATLSC EVAQAQTEVT WYKDGKKLSS SSKVRVEASG CMRQLVVQQA
VQADAGEYSC EAGDQRLSFH LDVSEPKVVF AKKQPAHREV QTEAGASATL SCEMAQAQTE
VTWYKDGKKL SSSSKVRMEA VGYTRRLVVQ QAGQADAGEY SCEARGKQLS FRLHVAEPKA
VFAKEQLVHR EVQAQAGASA TLNCEVAQAQ TEVMWYKDGK KLSSSSKVHV EAEGCTRRLV
VQQAGQADAG EYSCEAGGQR LSFRLHVAEP KAVFAKEQPA HREVQAEAGA SATLSCEVAQ
AKTEVMWYKG RKKLSSSSKV HVEVADCTRR LVVQQAGQAD AREYSCEAGG QQLSFSLHVA
EPKAVFAKEQ PVRREVQAEL GTSATLSCEM AQAQTEVTWY KDGKKLSSSP KVRMEAVGCT
RRLVVQQVGQ ADAGEYSCEA GGQRLSFGMH VAEPKVVFAK EQPAHRELQA EVGASATLSC
EVAQAQTEVT WYKDRKKLSS SSKVRVEAVG CTRRLVVQQV GQTEAGEYSC EAGGQRLSFR
LHVTEPKVVF AKEQPAHREV QAEAGTSTML SCEVAQAQTE VMWYKDRKKL SSSSKVRVEA
VGCTRRLVVQ EAVQADAGEY SCEAGGQRLS FHLHVAEPKV VFAKEQPACR VVQAEAGASA
TLSCVVAQGQ MEVTWYKDGK KLSSSSKVHV EAEGCTRRLV VQQAGQADAG EYSCEAGGQW
LSFHLHVAGP EPQISERPCR SEPLVVKEHE DIVLTATLAT PSVATVTWLK DGVEMRRSKR
HETASQGDTH TLTVHGAQVL DSAVYSCRVG AEGQDFPVQV EEVAAKFCRP LKPVCGELGG
TVTLACELSS ACAEVVWRRG STQLQVGKRF QMVAEGPVRL LTVLELRAED AGEYVCESRD
DHTSAQLTVS VPRVVKFMSG LSAVVAEEGC EATFQCVVSP SDAAVVWFRD GALLQPSEKF
AISQSGTSHS LTISGLVLED AGQITVEAEG VSSSAVLRVR EAPVLFKKKL EPQTVEERSS
VTLEVELTRP WPELRWTRNA AALAPGKNVE IHAEGARHRL VLHNVGFADR GFFGCETPDD
KTQAKLTVEM RQVRLIRGLQ AVEAQEQGTA TMEVQLSHAD VEGSWTRDGL RLQQGPTCHL
AVRGPTHTLT LSGLRPEDSG LMVFKAEGVH TSALLVVTEL PVNFSRPLQD VVTTEKEKVT
LECELSRPNV DVRWLKDGVE LRAGKTVGIA AQGTCRSLTI YRCEFADQGM YVCDAHDAQS
SASVKVQGRN IQIVRSLEDV EVMEKDSATF SCEVSHDEVP GQWFREGSKL RPSDNVRIRQ
EGRTYTLIYR RVLAEDAGEI KFVAENAESR AQLRVKELPV TLVRPLRDKI AMEKHRGVLE
CQVSRASAQV RWFKGSQELW PGPKYELVSD GLYRKLIISD VQAEDEDTYT CDAGDVKTSA
QFFVEEQSIT IVRGLQDVTV MEPAPAWFEC ETSIPSVRPP KWLLGKTVLQ AGGNVALEQE
GTVHRLMLRR TCSTMTGPVH FTIGKSRSSA RLVVSDIPVV LTRPLEPKTG RELQSVVLSC
DFRPAPKAVQ WYKDDTPLSA SEKFKMSLEG QMAELRILRL MPADAGVYRC QAGSAHSSTE
VTVEAREVTV TGPLQDAEAM EEGRASFSCE LSHEDEEVEW SLNGMPLYND SFHEISHRGR
CHMLVLKSVR RADAGTVCAS SPKVSTSAHL EVRVKPVVFL KGLDDLSAEE HGTLALQCEV
SDPEAHVVWR KDGVQLGPSD KYDFLHTAGT RGLVVHDLSP EDAGLYTCHV GSEETQARVS
VHDLHVGITK RLKTVEVLEG ESCSFECVLS HESASDPAMW TVGGKTVGSS SRFQATRQGR
KYILVVREAA PSDAGEVVFS VRSLTSKASL IVKERPATIM KPLEDQRVAP GEDVELCCEL
SRAGTPVRWL KDGKAIRKSQ KYDVVCEGTM AVLVIRGASL KDVGEYTCEV EASKSTASLC
VEEKANCFTE ELTNLQVEEK GTAVFTCKTE RPAATVTWRK GLLELRASRK HQPSQDGLAL
QLTISALEKA DSDIYTCDIG QAQSQAQLLV QGRRVHIIED LEDVDVQEGS SATFRCRISP
ANYEPVHWFL DKTPLHANEL NEIEAQPGGY HVLTLRQLAL KDSGTIYFEA GDQRASAALR
VTGKPSVFSR ELTDATITEG EDLTLVCETS ACDSPVCWTK DGKTLRGSAR YQLSHEGHRA
QLLITGATLQ DSGRYKCETG GACSSSIVRV HARPVRFQEA LKDLEVREGG AATLRCVLSS
VAAPVEWRCG DNVLRPGDKY SLRQEGAVLE LVVRNLRPQD SGRYSCSFGD QTTSATLTVT
ALPAQFIGKL RNKEATEGAT ATLRCELSKA APVEWRKGSE TIRDGDRYCL RQDGAMCELQ
IRGLAMVDAG EYSCVCGEER TSASLTIRAM PAHFIGRLRH QESTEGATAT LRCELSKVAP
VEWRKGRESL RDGDRHRLRQ DGAVCELQIC GLAVADAGEY SCVCGEERTS ATLTVKALLA
KFTEGLRNEE AVEGATAMLW CELSKVAPVE WRKGPKNLRD GDRYILRQEG TRCELQICGL
AMADAGEYLC VWGQERTSAT LTIRALPARF IEDVKNQEAR EGTTVMLQCE LNNAAPVEWR
KGSETLRDGD RYSLRQDGTK CELQIRGLSM VDTGEYSCVC GQERTSAMLT VRALPIKFTE
GLRNEEATEG ATATLRCELS KVAPVEWWKG HETLRDGDRH SLMQDGARCE LQIRGLVAED
AGEYLCMCGK ERTSAMLTVR ALPSKFIEGL RNEEATEGAT AILWCELSKV APVEWRKGHD
CLRDGDRHSL KQDGSRCELQ IRGLAVVDAG EYSCVCGQER TSAILTVRAL PARFIEDVKN
QEAREGATAV LQCELSKADP VEWRKGSETL RDGNRYSLRQ DGTRCELQIR GLSVADTGEY
SCVCGQERTS ATLTIRALPA RFTQDLKTKE ASEGATATLQ CELSKVAPVE WKKGPETLRD
GGRYSLKQDG TKCELQIHDL SVADAGEYSC ICGQERTSVT LTIRALPAKF TEGLRNEETM
EGATATLQCE LSKAAPVEWR KGLEALRDGD KYSLRQEGAV CELQIHGLAM ADTGVYSCVC
GQERTSATLT VRALPARFIE DMRSQKATEG TTVTLQCKLG KAAPVEWRKG PNTLRDGDRY
SLKQDGTRCQ LQIHGLVIAD AGEYSCICEQ ERTSATLTVR ALPARFIEDV RNHEATEGAT
AVLQCELSKV APVEWQKGSE TLRDGDRYSL RQDGTRCELQ IRGLAVEDTG EYLCVCGQER
TSATLTVRAL PARFIDNMTN QEAREGTTAT LQCELNKAAP VEWRKGPETL RDGDRHSLRQ
DGTRCELQIR GLAVADAGEY SCICGQERTS ATLTIRALPA KFTKGLKNEE ATEGATAMLQ
CELSKAAPVE WRKGPETLRD GDRYSLRQDG TRCELQIHGL SVADTGEYSC VCGQEKTSAT
LIVKAPQPVF REPLQSLQAE EGSTATLQCE LSEPTATVVW SKGGLQLRAN GRREPRLQGC
TAELVLRGLR REDTGEYTCT CGSQATSATL TVTAAPVRFL QELQPQEVDE GGTAHLRCEL
SRAGASVEWR KGSLELFPCA KYQMVQDGAA AELLVHGVEQ EDAGDYTCDT GHTHSMASLS
VRVPRPKFET RLQSLEQETG DIARLCCQLS DAESGATVQW LKEGVELHAG PKYEMRSQGA
MRELLIHQLE AKDTGEYACV TGGQKTTASL RVTEPEVTIV RGLVDAEVLA NEDVEFSCEV
SRAGATGMQW CLQGLPLQSN EVTEVTVQDG RIHTLRLKGV TPEDAGTVSF HLGNCASSAQ
LTIRAPEVTI LEPLQDVQLS EGQDASFQCR LSRASGQEAC WALGGVPLQD NEMNDITVEQ
GTLHLLTLHK VTLEDAGTVS FHVGTCSSEA QLKVTAKNTV VRGLENVEAL EGGEALFECQ
LSQPEVAAHT WLLDDEPVRT SENAEVVYFE NGLRHLLLLK NLRPQDSCRV TFLAGDMVTS
AFLTVRGWRL EILEPLKNAV VRAGAQALFT CTLSEVVPVG EASWYINGAA VQPDDADWTV
TADGSHHALL LRSAQLLHAG EVTFACRDAV ASARLTVLGL PDPPEDAEVV ACSSHTVTLS
WAAPMSDGGG GLCGYRVEVK EGAMGQWRLC HELVPGPECV VDGLAPGETY RFRVAAVGPV
GAGEPVHLPQ TVRLATPPKP VPPQPSAPES RQVAAGEDVC LELEVAAEAG EVIWHKGKER
IQPSGRFEVV SQGRQQMLVI RGFTAEDQGE YHCGPAQGST CPAAATFQVA LSPASVDEAP
PQPSLPLEAA QEGDLHQLWE ALARKRRMSR EPTLDSISEL PEEDGRSQHL PQEAEEVAPD
LSEGYSTADE LARTGEADLS HTSSDDESRA GTPSLVTYLK KAGRQGTSPL TSKVGAPAAP
SVKPQQQQEP LAAVRPPLGD LSTKDLGDPS MDKAAVKIQA AFKGYKVRKE MKQQEGPMFS
HTFGDTEAQV GDALRLECVV ASKADVRACW LKDGVELTDG RHHHIDQLGD GTCSLLITGL
GHADAGHYTC QVSNKFGQVA HSACVVVSGT ESEAESSSGG ELDDAFRRAA RRLHRLFRTK
SPAEVSDEEL FLSADEGPAE PEEPADWQTY HEDEHFICIR FEALTEARQA VTRFQEMFAT
LGIGVQINLV EEGPRRVEMR ISKEAPAPVV PPEPLPSLLT SDAAPVFLTE LQNQEVQDGY
PVSFDCVVRG QPMPSVRWFK DGKLLEEDDH YMINEDQQGG HQLIITAVVP ADMGVYRCLA
ENSVGVSSTK AELRVDLTST DYDTAADATE TSSYFSAQGY LSSREQEGTE STTDEGQLPQ
VVEELRDLQV APGTRLAKFQ LKVKGYPAPR LYWFKDGQPL TASAHIHMTD KKTLHTLEII
SVTREDSGQY AAYISNAMGA AYSSARLLVR GPDEPEEKPA SDVHEQLVPP RMLERFTPKK
VKKGSSITFS VKVEGHPAPT VHWLREEAER GVLWIGPDTP GYTMASSAQQ HSLVLLDVGR
QHQGTYTCIA SNAAGQALCS ASLRVSGLSK VEEQEKVKEA LISTFLQGTT QAVSAQGLET
ASFADLGGQR KGEPLAAKEA LRHLSLAEVG TEELLQKLTS QITEMVSAKI TQAKLQVPGG
DSDDDSKTPS ASPRHGRSRP SSSIQESSSE SEDGDARGEI FDIYVVTADY LPLGAEQDAI
ALREGQYVEV LDAAHPLRWL VRTKPTKSSP SRQGWVSPAY LDRRLKLSPE WGAAEAPEFP
GEAVSEDEYK SRLSSVIQEL LSSEQAFVEE LQFLQSHHLQ HLERCPHVPA AVASQKAVIF
RNVRDIGLFH SSFLQELQQC DTDDDVAMCF IKNQAAFEQY LEFLVGRVQA ESVVVSTAIQ
EFYKKYAEEA LSAGDPSQPP PPPLQHYLEQ PVERVQRYQG LLKELIRNKA RNRQNCALLE
QAYAVVSALP QRAENKLHVS LMEKYPGTLE ALGEPIRQGH FIVWEGAPGA RMPWKGHNRH
VFLFRNHLVI CKPRRDSRTD TFSYVFRNMM KLSSIDLNDQ VEGDDRAFEV WQEREDSVRK
YLLQARTAII KNSWVKEICG IQQRLALPVW RPPDFEEELA DCTAELGETV KLACRVTGTP
KPVISWYKDG KPVQVDPHHI LIEDPDGSCA LILDSLTSVD SGQYMCFAAS AAGNCSTLGK
ILVQVPPRFM NQVRASPFVE GEDAQFTCTI EGAPYPQIRW YKDGALLTPG SKFQTLSEPR
SGLLVLVIRA AGKEDLGLYE CELVNRLGST RASAELHIQS PTLQAREQCH REQLAGAVED
TTLERVDQIT SVLERLLGPR VPGPFTGDLT GPSPCPGGAP ALQETGSQPP VTGSSEAPAV
PQRVPQPLLH EGPEQEPEAI ARAQEWTVPI RMEGAARPGA GTGELLWDVH SHVVTETTQR
TYTYQAIDTH TARPPSMQVT IEDVQAQTGT MAQFEAVIEG DPQPSVTWYK DSVQLVDSTR
LSQQQEGTTY SLVLRHVASK DAGVYTCLAQ NAGGQVLCKA ELLVLGGDNE PDSEKQSHRR
KLHSFYEVKE EIGRGVFGFV KRVQHKGNKI LCAAKFIPLR SRTRAQAYRE RDILATLSHP
LVTGLLDQFE TRKTLILILE LCSSEELLDR LFRKGVVTEA EVKVYIQQLV EGLHYLHSHG
ILHLDIKPSN ILMVHPARED IKICDFGFAQ NITPAELQFS QYGSPEFVSP EIIQQNPVSE
ASDIWAMGVI SYLSLTCSSP FAGESDRATL LNVLEGRVSW SSPMAAHLSE DAKDFIKATL
QRASQARPSA AQCLSHPWFL KSMPAEEAHF INTKQLKFLL ARSRWQRSLM SYKSILVMRS
IPELLRGPPD SPSLGVARHL CRDTGGSSSS SSSSDNELAP FARAKSLPPS PVTHSPLLHP
RGFLRPSASL PEEAEATVPS AEASALPASP EGAGPPAAQG CVPRHSVIRS LFYQQAGESP
EHGALAPGSR RHPARRRHLL KGGYIAGALP GLREPLMEHC MLEEEAAREE QATLLTKAPS
FETALRLPAS GTHLAPGRSR SLDTEHDPPS TQRCSPEACC EAQRLPSAPS GGAPMRDMGH
PQGYKQLPST GGPPGTAQPE SPSLDHPWGQ PAPFCHAKQG SAPQEGCSPH SAVAPCPPGS
FPLGSCKEAP LVPSSPFLGQ PQVPPAPAKA SPPLDSKMGP GDISLPGRPK PGPCSSPGSA
SQASSSQVSS LRVGSSRVGT EPGPSLDAEG WSQEAEDLSD STPTLQRPQE QVTTRKFSLG
CRGGYAGVAG YGAFAFGGDA GGMLGQGPMW ARIAWAVSQS SEEQEEARAE SPLPQISARP
VPEVSRAPSR SSPEPAPWED VGQVSLVQIR DLSGDAEAAD TISLDISEVD PAYLNLSDLY
DIKYLPFEFM IFRKVPKPAQ PEPPSPMAEE ELAEFSEPMW PWQGEMGPHA GLEITEEPED
VDALLAEAAV GRKCKWSSPS RSLFHFPGRH LPLDEPAELG LRERVKASVE HISRILKGRP
EGLEKERPPR KKPGLASFRP SGLKSWDRAP TFLRELSDET VVLGQSVTLA CQVSAQPAAQ
ATWSKDGAPL ESSSRVLIST TLKNFQLLTI LVVAAEDLGV YTCSASNALG TVTTTGVLRK
AERPSSSPCP DIGEVYADGV LLVWKPVESY GPVTYIVQCS LEGGSWTTLA SDIFDCCYLT
SKLSRGGTYT FRTACVSKAG MGPYSSPSEQ VLLGGPSHLA SEEESQGRPA QPLPSTKTFA
FQTQIRRGRF SVVRQCWEKA SRRALAAKII PYRPKDKTAV LREYEALKGL RHPHLAQLHA
AYLSPRHLVL ILELCSGPEL LPCLAERASY SESEVKDYLW QMLSATQYLH AQHILHLDLR
SENMIITEYN LLKVVDLGNA QSLSQEKVLP SEKFKDYLET MELLEGQGAL PQTDIWAIGV
TAFIMLSAEY PVSSEGARDL QRGLRKGLIR LSRCYSGLSG GAVAFLRSTL CAQPWGRPCA
SSCLQCPWLT EQGPACSRPA PVTFPTARLR VFVRDREKRR ALLYKRHNLA QVR
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