ID A0A2K6DD96_MACNE Unreviewed; 278 AA.
AC A0A2K6DD96;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=COP9 signalosome subunit 7B {ECO:0000313|Ensembl:ENSMNEP00000033872.1};
GN Name=COPS7B {ECO:0000313|Ensembl:ENSMNEP00000033872.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000033872.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000033872.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes. The CSN
CC complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC pathway by mediating the deneddylation of the cullin subunits of SCF-
CC type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA,
CC ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
CC kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and
CC protects degradation by the Ubl system, respectively.
CC {ECO:0000256|ARBA:ARBA00025037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC {ECO:0000256|ARBA:ARBA00008482}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011726432.1; XM_011728130.1.
DR RefSeq; XP_011726433.1; XM_011728131.1.
DR RefSeq; XP_011726434.1; XM_011728132.1.
DR AlphaFoldDB; A0A2K6DD96; -.
DR SMR; A0A2K6DD96; -.
DR STRING; 9545.ENSMNEP00000033872; -.
DR Ensembl; ENSMNET00000058319.1; ENSMNEP00000033872.1; ENSMNEG00000040153.1.
DR GeneID; 105473926; -.
DR KEGG; mni:105473926; -.
DR CTD; 64708; -.
DR GeneTree; ENSGT00940000157155; -.
DR OrthoDB; 931897at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000040153; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR GO; GO:0000338; P:protein deneddylation; IEA:Ensembl.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR041481; CSN7_helixI.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR PANTHER; PTHR15350:SF8; COP9 SIGNALOSOME COMPLEX SUBUNIT 7B; 1.
DR Pfam; PF18392; CSN7a_helixI; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..159
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT COILED 188..219
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 278 AA; 31593 MW; A25C66B4AE15E24B CRC64;
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA NVQELAEGAN
AAYLQLLNLF AYGTYPDYIA NKKSLPELST AQQNKLKHLT IVSLASRMKC IPYSVLLKDL
EMRNLRELED LIIEAVYTDI IQGKLDQRNQ LLEVDFCIGR DIRKKDINNI VKTLHEWCDG
CEAVLLGIEQ QVLRANQYKE NHNRTQQQVE AEIACFQREK REVPLLNLIT TAFFWLPTSR
RHSKPPHPPR LRRWSSSWLN GSVRLTLSRG SPPRRCPK
//
