ID   A0A2K6DE28_MACNE        Unreviewed;      1117 AA.
AC   A0A2K6DE28;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Folliculin interacting protein 2 {ECO:0000313|Ensembl:ENSMNEP00000034176.1};
GN   Name=FNIP2 {ECO:0000313|Ensembl:ENSMNEP00000034176.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000034176.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000034176.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
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DR   RefSeq; XP_011751186.1; XM_011752884.1.
DR   AlphaFoldDB; A0A2K6DE28; -.
DR   Ensembl; ENSMNET00000058625.1; ENSMNEP00000034176.1; ENSMNEG00000040295.1.
DR   GeneID; 105488644; -.
DR   CTD; 57600; -.
DR   GeneTree; ENSGT00390000009391; -.
DR   OMA; IADTDKC; -.
DR   OrthoDB; 2725349at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000040295; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          42..1108
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          12..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          883..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        609..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        733..750
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        788..807
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1117 AA;  122547 MW;  738482BE1AEE40D6 CRC64;
     MAPTLLQKLF NKRGSSGSSA AASAQGRAPK EGPAFSWSCS EFDLNEIRLI VYQDCDRRGR
     QVLFDSKAVQ KIEEVTAQKT EDVPIKISAK CFQGSSSVSS VSSSSSSSIS FHSSSGGSSH
     HAKEQLPKYQ YTRPASDVNM LGEMMFGSVA MSYKGSTLKI HYIRSPPQLM ISKVFSARMG
     SFCGSTNNLQ DSFEYINQDP NLGKLNTNQN SLGPCRTGSN LAHSTPVDMP SRGQNEDRDS
     GIARSASLSS LLITPFPSPS SSTSSSSSYQ RRWLRSQTTS LENGIIPRRS TDETFSLAEE
     TCSSNPSMVR RKKIAISIIF SLCEKEEAQR NFQDFFFSHF PLFESHMNRL KSAIEKAMIS
     CRKIAESSLR VQFYVSRLME ALGEFRGTIW NLYSVPRIAE PVWLTMMSGT LEKNQLCQRF
     LKEFTLLIEQ INKNQFFAAL LTAVLTYHLA WVPTVMPVDH PPIKAFSEKR TSQSVNMLAK
     THPYNPLWAQ LGDLYGAIGS PVRLTRTVVV GKQKDLVQRI LYVLTYFLRC SELQENQLTW
     SGNHSEGDQV LNGSKIITAL EKGEVEESEY VVVTVRNEPA LVPPILPPTA AERQNPWPAG
     FPESPEGTDS RDLVLKPDKE ANRRPEQGFE ACSTGCQGPA SGASWKPQNA FCGDEKNKEV
     PQDGSSRLSS CEVLGAGMKM DQQAVCEPLK VEMSTRLPDR SVAWPCPDRH LWEKPPIEKV
     TFQIGSSTSP ESDFESRMKK MEERMKACGP SLEAREAADT AQDPQISRSP FKPGFQENVC
     CPQNRPSEGD EGESDKGFAE DRGSRNDTAT DAAGQLSHAA DLGAASHRGA GTAPGRLEAA
     TGLYVKAEEG PVLEPVAASS VQQGPGLVAP ANIPCGDDNK KANFRTEGDI PRNESSDSAL
     GDSDDEACTS AMLDLGHGGD RTGGSLEVEL PLPRSQSIST QNVRNFGRSL LAGYCPTYMP
     DLVLHGTGSD EKLKQCLVAD LVHTVHHPVL DEPIAEAVCI IADTDKWSVQ VATSQRKVTD
     NMKLGQDVLV SSQVSSLLQS ILQLYKLHLP ADFCIMHLED RLQEMYLKSK MLSEYLRGHT
     RVHVKELGVV LGIESNDLPL LTAIASTHSP YVAQILL
//