ID   A0A2K6DF49_MACNE        Unreviewed;       285 AA.
AC   A0A2K6DF49;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Zinc finger CCCH-type containing 12A {ECO:0000313|Ensembl:ENSMNEP00000034538.1};
GN   Name=ZC3H12A {ECO:0000313|Ensembl:ENSMNEP00000034538.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000034538.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000034538.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   AlphaFoldDB; A0A2K6DF49; -.
DR   Ensembl; ENSMNET00000058988.1; ENSMNEP00000034538.1; ENSMNEG00000040453.1.
DR   GeneTree; ENSGT00940000155107; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000040453; Expressed in lymph node and 10 other cell types or tissues.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd18729; PIN_Zc3h12-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   PANTHER; PTHR12876:SF10; ENDORIBONUCLEASE ZC3H12A; 1.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          51..91
FT                   /note="Rege-1 UBA-like"
FT                   /evidence="ECO:0000259|Pfam:PF18039"
FT   DOMAIN          137..275
FT                   /note="RNase NYN"
FT                   /evidence="ECO:0000259|Pfam:PF11977"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          92..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  32107 MW;  6DC2EFA67111AF4F CRC64;
     MSGPCGEKPV LEASPTMSLW EFEDSHSHSR QGTPRPAQEP AAEAASAVEL QMKVDFFRKL
     GYSSSEIHSV LQKLGVQADT NTVLGELVKH GTATERERQA SPDPCPQLPL VPRGGGTPKA
     PNLEPPLPEE DKEGSDLRPV VIDGSNVAMS HGNKEVFSCR GILLAVNWFL ERGHTDITVF
     VPSWRKEQPR PDVPITDQHI LWELEKKKIL VFTPSRRVGG KRVVCYDDRF IVKLAYESDG
     IVVSNDTYRD LQGERQEWKR FIEERLLMYS FVNDNKACHR PLLRN
//