ID   A0A2K6DG18_MACNE        Unreviewed;      1495 AA.
AC   A0A2K6DG18;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Leucine rich repeat containing 7 {ECO:0000313|Ensembl:ENSMNEP00000034841.1};
GN   Name=LRRC7 {ECO:0000313|Ensembl:ENSMNEP00000034841.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000034841.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000034841.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC       {ECO:0000256|ARBA:ARBA00007772}.
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DR   Ensembl; ENSMNET00000059293.1; ENSMNEP00000034841.1; ENSMNEG00000040393.1.
DR   GeneTree; ENSGT00940000156262; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000040393; Expressed in temporal lobe and 6 other cell types or tissues.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF48; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 7; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00364; LRR_BAC; 10.
DR   SMART; SM00365; LRR_SD22; 6.
DR   SMART; SM00369; LRR_TYP; 11.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS51450; LRR; 3.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1408..1493
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          668..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          733..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          791..815
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          830..897
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1142..1168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1239..1273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1287..1328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..714
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        791..811
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        837..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1290..1310
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1495 AA;  167955 MW;  7DFA0B6A71D5668E CRC64;
     MQCLEMTTKR KIIGRLVPCR CFRGEEEIIS VLDYSHCSLQ QVPKEVFNFE RTLEELYLDA
     NQIEELPKQL FNCQALRKLS IPDNDLSNLP TTIASLVNLK ELDISKNGVQ EFPENIKCCK
     CLTIIEASVN PISKLPDGFT QLLNLTQLYL NDAFLEFLPA NFGRLVKLRI LELRENHLKT
     LPKSMHKLAQ LERLDLGNNE FGELPEVLDQ IQNLRELWMD NNALQVLPGS IGKLKMLVYL
     DMSKNRIETV DMDISGCEAL EDLLLSSNML QQLPDSIGLL KKLTTLKVDD NQLTMLPNTI
     GNLSLLEEFD CSCNELESLP STIGYLHSLR TLAVDENFLP ELPREIGSCK NVTVMSLRSN
     KLEFLPEEIG QMQKLRVLNL SDNRLKNLPF SFTKLKELAA LWLSDNQSKA LIPLQTEAHP
     ETKQRVLTNY MFPQQPRGDE DFQSDSDSFN PTLWEEQRQQ RMTVAFEFED KKEDDENAGK
     VKDLSCQAPW ERGQRGITLQ PARLSGDCCT PWARCDQQIQ DMPVPQNDPQ LAWGCITGLQ
     QDRSMCTPLP VAAQSTTLPS LSGRQVEINL KRYPTPYPED LKNMVKSVQN LVGKPSHGVR
     VENSNPTANT EQTVKEKYEH KWPVAPKEIT VEDSFVHPAN EMRIGELHPS LAETPLYPPK
     LVLLGKDKKE STDESEVDKT HCLNNSVSSG TYSDYSPSQA SSGSSNTRVK VGSLQTTAKD
     AVHNSLWGNR IAPSFPQPLD SKPLLSQREA VPPGSIPQRP DRLPMSDTFT DNWTDGSHYD
     NTGFVAEETA AENANSNPLL SSKSRSTSSH GRRPLIRQDR IVGVPLELEQ STHRHTPETE
     VPPSNPWQNW TRTPSPFEDR TAFPSKLETT PTTSPLPERK EHIKESTEIP SPFSPGVPWE
     YHDSNPNRSL SNVFSQIHCR PDSSKGVISI SKSTERLSPL MKDIKSNKFK KSQSIDEIDI
     GTYKVYNIPL ENYASGSDHL GSHERPDKML GPEHGMSSMS RSQSVPMLDD EMLTYGSSKG
     PQQQKASMTK KVYQFDQSFN PQGSVEVKAE KRIPPPFQHN PEYMQQASKN ITKDLISPRA
     YRGYPPMEQM FSFSQPSVNE DAVVNAQFAS QGARAGFLRR ADSLVSATEM AMFRRVNEPH
     ELPATDRYGR PPYRGGLDRQ SSVTVTESQF LKRNGRYEDE HPSYQEVKAQ AGSFPVKNLT
     QRRPLSARSY STESYGASQT RPVSARPTMA ALLEKIPSDY NLGNYGDKPS DNSDLKTRPT
     PVKGEESCGK MPADWRQQLL RHIEARRLDR TPSQQSNILD NGQEDVSPSG QWNPYPLGRR
     DVPPDTITKK AGSHIQTLMG SQSLQHRSRE QQPYEGNINK VTIQQFQSPL PIQIPSSQAT
     RGPQPGRCLI QTKGQRSMDG YPEQFCVRIE KNPGLGFSIS GGISGQGNPF KPSDKGIFVT
     RVQPDGPASN LLQPGDKILQ ANGHSFVHME HEKAVLLLKS FQNTVDLVIQ RELTV
//